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Mechanistic studies of metal-dependent DNA cleavage in Type II topoisomerase toward the rational design of novel anticancer drugs


Polyamine-containing etoposide derivatives as poisons of human type II topoisomerases: Differential effects on topoisomerase IIα and IIβ

Author(s): Alexandria A. Oviatt, Jissy A. Kuriappan, Elirosa Minniti, Kendra R. Vann, Princess Onuorah, Anna Minarini, Marco De Vivo, Neil Osheroff
Published in: Bioorganic & Medicinal Chemistry Letters, Issue 28/17, 2018, Page(s) 2961-2968, ISSN 0960-894X
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.bmcl.2018.07.010

Smoothed Potential MD Simulations for Dissociation Kinetics of Etoposide To Unravel Isoform Specificity in Targeting Human Topoisomerase II

Author(s): Jissy A. Kuriappan, Neil Osheroff, Marco De Vivo
Published in: Journal of Chemical Information and Modeling, Issue 59/9, 2019, Page(s) 4007-4017, ISSN 1549-9596
Publisher: American Chemical Society
DOI: 10.1021/acs.jcim.9b00605

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