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Image-based High-resolution In-silico Modeling of Total Cardiac Function

Objective

Advances in medical imaging have enabled unprecedented ability to image cardiac anatomy and function. So far these technologies have had relatively modest clinical impact as the analysis of such rich multi-modal datasets has proven challenging.
In silico models hold vast potential to better harness such datasets by enabling their integration into quantitative frameworks that can aid in gaining better mechanistic insight into cardiac function in health and disease, and thus paving the way towards optimal therapeutic strategies.

Our objective is to develop the most advanced biophysically detailed in-silico model of total electro-mechano-fluidic function of the heart.
This model will be parametrized, verified and used to study cause-effect relationships between flow and pressure and their impact upon pumping performance.
A novel set of features such as combined models of both heart and attached outflow vessels and the computational efficiency will provide a unique platform for translational research.

This ambitious endeavor is feasible only by combining the expertise of the applicant in modeling soft tissue mechanics and his supervisors in modeling electrophysiology (Gernot Plank, MUG) and blood flow (Shawn Shadden, UC Berkeley).
Clinical input and datasets for model parametrization and validation are provided by Titus Kühne (DHZ Berlin) and by clinical collaborators of Prof. Shadden at UCSF.
During the return-phase, the applicant will use the infrastructure of Prof. Plank’s lab and the large network of academic and industrial collaborations as an incubator for building up his own research group in computational hemodynamics. This is ideal in many regards, as the expertise of the applicant's group will be entirely orthogonal to the expertise in Prof. Plank's lab, thus promoting a fast pathway towards full indepence, and core expertise necessary for further developing and maintaining a highly complex computing environment is synergistically shared between the labs.

Field of science

  • /natural sciences/physical sciences/classical mechanics/fluid mechanics/fluid dynamics
  • /engineering and technology/medical engineering/diagnostic imaging
  • /natural sciences/mathematics/applied mathematics/mathematical model
  • /natural sciences/computer and information sciences/computational science/multiphysics
  • /natural sciences/physical sciences/classical mechanics/fluid mechanics/computational fluid dynamics
  • /natural sciences/computer and information sciences/software/application software/simulation software

Call for proposal

H2020-MSCA-IF-2016
See other projects for this call

Funding Scheme

MSCA-IF-GF - Global Fellowships

Coordinator

MEDIZINISCHE UNIVERSITAT GRAZ
Address
Auenbruggerplatz 2
8036 Graz
Austria
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 218 176,20

Partners (1)

THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
United States
Address
Franklin Street 1111, 12 Floor
94607 Oakland Ca
Activity type
Higher or Secondary Education Establishments