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Visible Attributes through Genomics: Broadened Forensic Use of DNA for Constructing Composite Sketches from Traces

Deliverables

Training curricula addressing different target groups from forensic institutes and the police on technical, societal, regulatory challenges of constructing composite sketches from DNA in forensic practice

This deliverable provides a report on training curricula addressing different relevant target groups such as from forensic institutes and the police, on technical, societal, regulatory challenges of constructing composite sketches from DNA in forensic practice including the various elements of the project outcome (markers, analytical prototype tools, software prototype tools, forensic validation, end-user implementation, ethical, regulatory and societal aspects).

Report on challenges to the implementation of FDP in an ethical and societally responsible manner, with special emphasis on privacy and data protection

This deliverable provides a report summarizing the identified challenges to the practical implementation of Forensic DNA Phenotyping in an ethical and societally responsible manner, with special emphasis on privacy and data protection.

Report on implemented MPS prototype tool(s) on TRL 5 for constructing basic composite sketches from DNA in forensic practice

This deliverable provides a report summarizing the outcome of the practical user validation and implementation of the developed analytical prototype tool(s) based on massively parallel sequencing for constructing basic composite sketches from DNA in the routine DNA service environment.

Report on new integrative statistical framework for combined appearance, age, and ancestry prediction from DNA

This deliverable provides the summary report describing the newly developed integrative statistical framework for combined appearance, age, and ancestry prediction from DNA.

Report on recommendations to address the ethical and societal challenges, considering best practice examples, with special emphasis on how privacy-enhancing features can be designed into technologies, legal and regulatory infrastructures, and processes

This deliverable provides a report on recommendations to address the ethical and societal challenges of practically implementing Forensic DNA Phenotyping by considering how privacy-enhancing features can be designed into technologies, legal and regulatory infrastructures, and processes.

Report on new MPS prototype tool(s) for constructing basic composite sketches from DNA

This deliverable provides the summary report describing newly developed analytical prototype tool(s) based on massively parallel sequencing for constructing basic composite sketches from DNA.

Report on previously validated markers for predicting basic appearance, age, ancestry from DNA

This deliverable provides the a list of previously validated markers for predicting basic appearance, age, ancestry from DNA and makes them available to work packages 3 and 4 for analytical and statistical prototype tool developments.

Report on new markers for predicting as detailed as possible appearance, age, ancestry from DNA

This deliverable provides a list of newly identified markers for predicting as detailed as possible appearance, age, ancestry from DNA, and makes them available to work packages 3 and 4 for analytical and statistical prototype tool developments.

Report on new prototype software at TLR 5 level for constructing composite sketches from DNA

This delivery provides the summary report of the newly developed prototype software for constructing composite sketches from DNA.

Report on forensic developmental validation of new MPS prototype tool(s) for constructing basic composite sketches from DNA

This deliverable provides the summary report describing the outcomes of the forensic developmental validation of the newly developed analytical prototype tool(s) based on massively parallel sequencing for constructing basic composite sketches from DNA.

Report on forensic developmental validation of new MPS prototype tool(s) for constructing enhanced composite sketches from DNA

This deliverable provides the summary report describing the outcomes of the forensic developmental validation of the newly developed analytical prototype tool(s) based on massively parallel sequencing for constructing enhanced composite sketches from DNA.

Report on new MPS prototype tool(s) for constructing enhanced composite sketches from DNA

This deliverable provides the summary report describing newly developed analytical prototype tool(s) based on massively parallel sequencing for constructing enhanced composite sketches from DNA.

Report on current and expected legal and regulatory landscape at (a) EU level and (b) specific for each Participant country

This deliverable provides a report summarizing the carried-out systematic assessment of the current and expected legal and regulatory landscape in EU Member States in general, and in each Participant country in particular, regarding the practical use of Forensic DNA Phenotyping.

Report on European-wide inquiry on training needs among stake holders and end users

This deliverable provides a report summarizing the outcome of a European-wide inquiry on training needs on the topic of Forensic DNA Phenotyping among the major potential end user groups such as from forensic practice, police, and law enforcement.

Project website publically online describing the Project and the Consortium , and regularly updated on the Project achievements such as publications etc.

The deliverable provides the VISAGE website representing the project's gateway to the outside world, i.e. the general public including all relevant target groups and interested scientific communities, where the Consortium is introduced with its participants and advisors, the Project is broadly described, and public achievements are presented and regularly updated.

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Publications

Age Estimation with DNA: From Forensic DNA Fingerprinting to Forensic (Epi)Genomics: A Mini-Review

Author(s): Walther Parson
Published in: Gerontology, Issue Online first, 23-01-2018, 2018, Page(s) 1-7, ISSN 0304-324X
DOI: 10.1159/000486239

From forensic epigenetics to forensic epigenomics: broadening DNA investigative intelligence

Author(s): Athina Vidaki, Manfred Kayser
Published in: Genome Biology, Issue 18/1, 2017, ISSN 1474-760X
DOI: 10.1186/s13059-017-1373-1

Update on the predictability of tall stature from DNA markers in Europeans

Author(s): Fan Liu, Kaiyin Zhong, Xiaoxi Jing, André G. Uitterlinden, A. Emile J. Hendriks, Stenvert L.S. Drop, Manfred Kayser
Published in: Forensic Science International: Genetics, 2019, ISSN 1872-4973
DOI: 10.1016/j.fsigen.2019.05.006

Forensic DNA phenotyping in Europe: views “on the ground” from those who have a professional stake in the technology

Author(s): Gabrielle Samuel, Barbara Prainsack
Published in: New Genetics and Society, Issue 38/2, 2019, Page(s) 119-141, ISSN 1463-6778
DOI: 10.1080/14636778.2018.1549984

Novel genetic loci affecting facial shape variation in humans

Author(s): Ziyi Xiong, Gabriela Dankova, Laurence J Howe, Myoung Keun Lee, Pirro G Hysi, Markus A de Jong, Gu Zhu, Kaustubh Adhikari, Dan Li, Yi Li, Bo Pan, Eleanor Feingold, Mary L Marazita, John R Shaffer, Kerrie McAloney, Shu-Hua Xu, Li Jin, Sijia Wang, Femke MS de Vrij, Bas Lendemeijer, Stephen Richmond, Alexei Zhurov, Sarah Lewis, Gemma C Sharp, Lavinia Paternoster, Holly Thompson, Rolando Gonzalez-Jose
Published in: eLife, Issue 8, 2019, ISSN 2050-084X
DOI: 10.7554/eLife.49898

Genome-Wide Association Studies Identify Multiple Genetic Loci Influencing Eyebrow Color Variation in Europeans

Author(s): Fuduan Peng, Gu Zhu, Pirro G. Hysi, Ryan J. Eller, Yan Chen, Yi Li, Merel A. Hamer, Changqing Zeng, Racquel L. Hopkins, Case L. Jacobus, Paige L. Wallace, André G. Uitterlinden, M. Arfan Ikram, Tamar Nijsten, David L. Duffy, Sarah E. Medland, Timothy D. Spector, Susan Walsh, Nicholas G. Martin, Fan Liu, Manfred Kayser
Published in: Journal of Investigative Dermatology, Issue 139/7, 2019, Page(s) 1601-1605, ISSN 0022-202X
DOI: 10.1016/j.jid.2018.12.029

True colors: A literature review on the spatial distribution of eye and hair pigmentation

Author(s): Maria-Alexandra Katsara, Michael Nothnagel
Published in: Forensic Science International: Genetics, Issue 39, 2019, Page(s) 109-118, ISSN 1872-4973
DOI: 10.1016/j.fsigen.2019.01.001

DNA-based predictive models for the presence of freckles

Author(s): Magdalena Kukla-Bartoszek, Ewelina Pośpiech, Anna Woźniak, Michał Boroń, Joanna Karłowska-Pik, Paweł Teisseyre, Magdalena Zubańska, Agnieszka Bronikowska, Tomasz Grzybowski, Rafał Płoski, Magdalena Spólnicka, Wojciech Branicki
Published in: Forensic Science International: Genetics, Issue 42, 2019, Page(s) 252-259, ISSN 1872-4973
DOI: 10.1016/j.fsigen.2019.07.012

Civil society stakeholder views on forensic DNA phenotyping: Balancing risks and benefits

Author(s): Gabrielle Samuel, Barbara Prainsack
Published in: Forensic Science International: Genetics, Issue 43, 2019, Page(s) 102157, ISSN 1872-4973
DOI: 10.1016/j.fsigen.2019.102157

Building a custom large-scale panel of novel microhaplotypes for forensic identification using MiSeq and Ion S5 massively parallel sequencing systems

Author(s): M. de la Puente, C. Phillips, C. Xavier, J. Amigo, A. Carracedo, W. Parson, M.V. Lareu
Published in: Forensic Science International: Genetics, Issue 45, 2020, Page(s) 102213, ISSN 1872-4973
DOI: 10.1016/j.fsigen.2019.102213

The use of forensic DNA phenotyping in predicting appearance and biogeographic ancestry

Author(s): Peter M. Schneider, Barbara Prainsack, Manfred Kayser
Published in: Deutsches Aerzteblatt Online, 2019, ISSN 1866-0452
DOI: 10.3238/arztebl.2019.0873