Visible Attributes through Genomics: Broadened Forensic Use of DNA for Constructing Composite Sketches from Traces

Deliverables

Documents, reports (15)

Training curricula addressing different target groups from forensic institutes and the police on technical, societal, regulatory challenges of constructing composite sketches from DNA in forensic practice

This deliverable provides a report on training curricula addressing different relevant target groups such as from forensic institutes and the police, on technical, societal, regulatory challenges of constructing composite sketches from DNA in forensic practice including the various elements of the project outcome (markers, analytical prototype tools, software prototype tools, forensic validation, end-user implementation, ethical, regulatory and societal aspects).

Report on challenges to the implementation of FDP in an ethical and societally responsible manner, with special emphasis on privacy and data protection

This deliverable provides a report summarizing the identified challenges to the practical implementation of Forensic DNA Phenotyping in an ethical and societally responsible manner, with special emphasis on privacy and data protection.

Report on implemented MPS prototype tool(s) on TRL 5 for constructing basic composite sketches from DNA in forensic practice

This deliverable provides a report summarizing the outcome of the practical user validation and implementation of the developed analytical prototype tool(s) based on massively parallel sequencing for constructing basic composite sketches from DNA in the routine DNA service environment.

Report on new integrative statistical framework for combined appearance, age, and ancestry prediction from DNA

This deliverable provides the summary report describing the newly developed integrative statistical framework for combined appearance, age, and ancestry prediction from DNA.

Report on recommendations to address the ethical and societal challenges, considering best practice examples, with special emphasis on how privacy-enhancing features can be designed into technologies, legal and regulatory infrastructures, and processes

This deliverable provides a report on recommendations to address the ethical and societal challenges of practically implementing Forensic DNA Phenotyping by considering how privacy-enhancing features can be designed into technologies, legal and regulatory infrastructures, and processes.

Report on new MPS prototype tool(s) for constructing basic composite sketches from DNA

This deliverable provides the summary report describing newly developed analytical prototype tool(s) based on massively parallel sequencing for constructing basic composite sketches from DNA.

Report on previously validated markers for predicting basic appearance, age, ancestry from DNA

This deliverable provides the a list of previously validated markers for predicting basic appearance, age, ancestry from DNA and makes them available to work packages 3 and 4 for analytical and statistical prototype tool developments.

Report on new markers for predicting as detailed as possible appearance, age, ancestry from DNA

This deliverable provides a list of newly identified markers for predicting as detailed as possible appearance, age, ancestry from DNA, and makes them available to work packages 3 and 4 for analytical and statistical prototype tool developments.

Report on new prototype software at TLR 5 level for constructing composite sketches from DNA

This delivery provides the summary report of the newly developed prototype software for constructing composite sketches from DNA.

Report on implemented MPS prototype tool(s) and software on TRL 5 for constructing enhanced composite sketches from DNA in routine forensic practice

This deliverable provides a report summarizing the outcome of the practical user validation and implementation of the developed analytical prototype tools based on massively parallel sequencing and the developed prototype software tool for constructing enhanced composite sketches from DNA in the routine DNA service environment

Report on forensic developmental validation of new MPS prototype tool(s) for constructing basic composite sketches from DNA

This deliverable provides the summary report describing the outcomes of the forensic developmental validation of the newly developed analytical prototype tool(s) based on massively parallel sequencing for constructing basic composite sketches from DNA.

Report on forensic developmental validation of new MPS prototype tool(s) for constructing enhanced composite sketches from DNA

This deliverable provides the summary report describing the outcomes of the forensic developmental validation of the newly developed analytical prototype tool(s) based on massively parallel sequencing for constructing enhanced composite sketches from DNA.

Report on new MPS prototype tool(s) for constructing enhanced composite sketches from DNA

This deliverable provides the summary report describing newly developed analytical prototype tool(s) based on massively parallel sequencing for constructing enhanced composite sketches from DNA.

Report on current and expected legal and regulatory landscape at (a) EU level and (b) specific for each Participant country

This deliverable provides a report summarizing the carried-out systematic assessment of the current and expected legal and regulatory landscape in EU Member States in general, and in each Participant country in particular, regarding the practical use of Forensic DNA Phenotyping.

Report on European-wide inquiry on training needs among stake holders and end users

This deliverable provides a report summarizing the outcome of a European-wide inquiry on training needs on the topic of Forensic DNA Phenotyping among the major potential end user groups such as from forensic practice, police, and law enforcement.

Websites, patent fillings, videos etc. (1)

Project website publically online describing the Project and the Consortium , and regularly updated on the Project achievements such as publications etc.

The deliverable provides the VISAGE website representing the project's gateway to the outside world, i.e. the general public including all relevant target groups and interested scientific communities, where the Consortium is introduced with its participants and advisors, the Project is broadly described, and public achievements are presented and regularly updated.

Other (2)

Kick-off meeting for the “Train-the-trainers” workshop series on technical, societal, regulatory challenges of constructing composite sketches from DNA in forensic practice

This deliverable provides the kickoff meeting for the Trainthetrainers workshop series where the developed training curricula on technical societal regulatory challenges of constructing composite sketches from DNA in forensic practice will be executed so that the knowledge easily multiples by enabling the trained trainers to run their own training events in their own EU Member States using their local languages

Report on three expert symposia to stimulate a discussion on the legal admissibility of forensic DNA phenotyping in EU Member States where it is prohibited by law at present

This deliverable provides a report that jointly presents and compares the outcomes of three expert symposia involving social scientists law scientists representatives of political parties organizations and civil society groups NGOs as well as forensic scientists and practitioners police and law enforcement taken place to stimulate a broad discussion on the legal admissibility of Forensic DNA Phenotyping in example EU Member States where it is prohibited by law at the time

Publications

Peer reviewed articles (25)

Development and validation of the VISAGE AmpliSeq basic tool to predict appearance and ancestry from DNA

Author(s): Catarina Xavier, Maria de la Puente, Ana Mosquera-Miguel, Ana Freire-Aradas, Vivian Kalamara, Athina Vidaki, Theresa E. Gross, Andrew Revoir, Ewelina Pośpiech, Ewa Kartasińska, Magdalena Spólnicka, Wojciech Branicki, Carole E. Ames, Peter M. Schneider, Carsten Hohoff, Manfred Kayser, Christopher Phillips, Walther Parson
Published in: Forensic Science International: Genetics, 48, 2020, Page(s) 102336, ISSN 1872-4973
Publisher: Elsevier BV
DOI: 10.1016/j.fsigen.2020.102336

Evaluation of supervised machine-learning methods for predicting appearance traits from DNA

Author(s): Maria-Alexandra Katsara, Wojciech Branicki, Susan Walsh, Manfred Kayser, Michael Nothnagel
Published in: Forensic Science International: Genetics, 53, 2021, Page(s) 102507, ISSN 1872-4973
Publisher: Elsevier BV
DOI: 10.1016/j.fsigen.2021.102507

Evaluation of the VISAGE Basic Tool for Appearance and Ancestry Prediction Using PowerSeq Chemistry on the MiSeq FGx System

Author(s): Leire Palencia-Madrid, Catarina Xavier, María de la Puente, Carsten Hohoff, Christopher Phillips, Manfred Kayser, Walther Parson
Published in: Genes, 11/6, 2020, Page(s) 708, ISSN 2073-4425
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/genes11060708

Evaluation of the VISAGE basic tool for appearance and ancestry inference using ForenSeq® chemistry on the MiSeq FGx® system.

Author(s): Catarina Xavier, Maria de la Puente, Maja Sidstedt, Klara Junker, Angelika Minawi, Martina Unterländer, Yann Chantrel, François-Xavier Laurent, Anna Delest, Carsten Hohoff, Ingo Bastisch, Johannes Hedman, Kristiaan J van der Gaag, Titia Sijen, Walther Parson
Published in: Forensic Science International Genetics, 58, 2022, Page(s) 102675, ISSN 1872-4973
Publisher: Elsevier BV
DOI: 10.1016/j.fsigen.2022.102675

Epigenetic age prediction in semen – marker selection and model development

Author(s): Aleksandra Pisarek, Ewelina Pośpiech, Antonia Heidegger, Catarina Xavier, Anna Papież, Danuta Piniewska-Róg, Vivian Kalamara, Ramya Potabattula, Michał Bochenek, Marta Sikora-Polaczek, Aneta Macur, Anna Woźniak, Jarosław Janeczko, Christopher Phillips, Thomas Haaf, Joanna Polańska, Walther Parson, Manfred Kayser, Wojciech Branicki
Published in: Aging, 13/15, 2021, Page(s) 19145-19164, ISSN 1945-4589
Publisher: Aging (Albany New York)
DOI: 10.18632/aging.203399

Development and optimization of the VISAGE basic prototype tool for forensic age estimation

Author(s): A. Heidegger, C. Xavier, H. Niederstätter, M. de la Puente, E. Pośpiech, A. Pisarek, M. Kayser, W. Branicki, W. Parson
Published in: Forensic Science International: Genetics, 48, 2020, Page(s) 102322, ISSN 1872-4973
Publisher: Elsevier BV
DOI: 10.1016/j.fsigen.2020.102322

Development and Evaluation of the Ancestry Informative Marker Panel of the VISAGE Basic Tool

Author(s): María de la Puente, Jorge Ruiz-Ramírez, Adrián Ambroa-Conde, Catarina Xavier, Jacobo Pardo-Seco, Jose Álvarez-Dios, Ana Freire-Aradas, Ana Mosquera-Miguel, Theresa E. Gross, Elaine Y. Y. Cheung, Wojciech Branicki, Michael Nothnagel, Walther Parson, Peter M. Schneider, Manfred Kayser, Ángel Carracedo, Maria Victoria Lareu, Christopher Phillips
Published in: Genes, 12/8, 2021, Page(s) 1284, ISSN 2073-4425
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/genes12081284

The impact of correlations between pigmentation phenotypes and underlying genotypes on genetic prediction of pigmentation traits

Author(s): Yan Chen, Wojciech Branicki, Susan Walsh, Michael Nothnagel, Manfred Kayser, Fan Liu
Published in: Forensic Science International: Genetics, 50, 2021, Page(s) 102395, ISSN 1872-4973
Publisher: Elsevier BV
DOI: 10.1016/j.fsigen.2020.102395

Testing the impact of trait prevalence priors in Bayesian-based genetic prediction modeling of human appearance traits

Author(s): Maria-Alexandra Katsara, Wojciech Branicki, Ewelina Pośpiech, Pirro Hysi, Susan Walsh, Manfred Kayser, Michael Nothnagel
Published in: Forensic Science International: Genetics, 50, 2021, Page(s) 102412, ISSN 1872-4973
Publisher: Elsevier BV
DOI: 10.1016/j.fsigen.2020.102412

Age Estimation with DNA: From Forensic DNA Fingerprinting to Forensic (Epi)Genomics: A Mini-Review

Author(s): Walther Parson
Published in: Gerontology, Online first, 23-01-2018, 2018, Page(s) 1-7, ISSN 0304-324X
Publisher: S. Karger AG
DOI: 10.1159/000486239

From forensic epigenetics to forensic epigenomics: broadening DNA investigative intelligence

Author(s): Athina Vidaki, Manfred Kayser
Published in: Genome Biology, 18/1, 2017, ISSN 1474-760X
Publisher: BMC
DOI: 10.1186/s13059-017-1373-1

Update on the predictability of tall stature from DNA markers in Europeans

Author(s): Fan Liu, Kaiyin Zhong, Xiaoxi Jing, André G. Uitterlinden, A. Emile J. Hendriks, Stenvert L.S. Drop, Manfred Kayser
Published in: Forensic Science International: Genetics, 2019, ISSN 1872-4973
Publisher: Elsevier BV
DOI: 10.1016/j.fsigen.2019.05.006

Forensic DNA phenotyping in Europe: views “on the ground” from those who have a professional stake in the technology

Author(s): Gabrielle Samuel, Barbara Prainsack
Published in: New Genetics and Society, 38/2, 2019, Page(s) 119-141, ISSN 1463-6778
Publisher: Carfax Publishing Ltd.
DOI: 10.1080/14636778.2018.1549984

Novel genetic loci affecting facial shape variation in humans

Author(s): Ziyi Xiong, Gabriela Dankova, Laurence J Howe, Myoung Keun Lee, Pirro G Hysi, Markus A de Jong, Gu Zhu, Kaustubh Adhikari, Dan Li, Yi Li, Bo Pan, Eleanor Feingold, Mary L Marazita, John R Shaffer, Kerrie McAloney, Shu-Hua Xu, Li Jin, Sijia Wang, Femke MS de Vrij, Bas Lendemeijer, Stephen Richmond, Alexei Zhurov, Sarah Lewis, Gemma C Sharp, Lavinia Paternoster, Holly Thompson, Rolando Gonzalez-Jose
Published in: eLife, 8, 2019, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.7554/eLife.49898

Genome-Wide Association Studies Identify Multiple Genetic Loci Influencing Eyebrow Color Variation in Europeans

Author(s): Fuduan Peng, Gu Zhu, Pirro G. Hysi, Ryan J. Eller, Yan Chen, Yi Li, Merel A. Hamer, Changqing Zeng, Racquel L. Hopkins, Case L. Jacobus, Paige L. Wallace, André G. Uitterlinden, M. Arfan Ikram, Tamar Nijsten, David L. Duffy, Sarah E. Medland, Timothy D. Spector, Susan Walsh, Nicholas G. Martin, Fan Liu, Manfred Kayser
Published in: Journal of Investigative Dermatology, 139/7, 2019, Page(s) 1601-1605, ISSN 0022-202X
Publisher: Blackwell Publishing Inc.
DOI: 10.1016/j.jid.2018.12.029

True colors: A literature review on the spatial distribution of eye and hair pigmentation

Author(s): Maria-Alexandra Katsara, Michael Nothnagel
Published in: Forensic Science International: Genetics, 39, 2019, Page(s) 109-118, ISSN 1872-4973
Publisher: Elsevier BV
DOI: 10.1016/j.fsigen.2019.01.001

DNA-based predictive models for the presence of freckles

Author(s): Magdalena Kukla-Bartoszek, Ewelina Pośpiech, Anna Woźniak, Michał Boroń, Joanna Karłowska-Pik, Paweł Teisseyre, Magdalena Zubańska, Agnieszka Bronikowska, Tomasz Grzybowski, Rafał Płoski, Magdalena Spólnicka, Wojciech Branicki
Published in: Forensic Science International: Genetics, 42, 2019, Page(s) 252-259, ISSN 1872-4973
Publisher: Elsevier BV
DOI: 10.1016/j.fsigen.2019.07.012

Civil society stakeholder views on forensic DNA phenotyping: Balancing risks and benefits

Author(s): Gabrielle Samuel, Barbara Prainsack
Published in: Forensic Science International: Genetics, 43, 2019, Page(s) 102157, ISSN 1872-4973
Publisher: Elsevier BV
DOI: 10.1016/j.fsigen.2019.102157

Building a custom large-scale panel of novel microhaplotypes for forensic identification using MiSeq and Ion S5 massively parallel sequencing systems

Author(s): M. de la Puente, C. Phillips, C. Xavier, J. Amigo, A. Carracedo, W. Parson, M.V. Lareu
Published in: Forensic Science International: Genetics, 45, 2020, Page(s) 102213, ISSN 1872-4973
Publisher: Elsevier BV
DOI: 10.1016/j.fsigen.2019.102213

The use of forensic DNA phenotyping in predicting appearance and biogeographic ancestry

Author(s): Peter M. Schneider, Barbara Prainsack, Manfred Kayser
Published in: Deutsches Aerzteblatt Online, 2019, ISSN 1866-0452
Publisher: Deutscher Arzte-Verlag
DOI: 10.3238/arztebl.2019.0873

Impact of excessive alcohol abuse on age prediction using the VISAGE enhanced tool for epigenetic age estimation in blood

Author(s): Danuta Piniewska-Róg, Antonia Heidegger, Ewelina Pośpiech, Catarina Xavier, Aleksandra Pisarek, Agata Jarosz, Anna Woźniak, Marta Wojtas, Christopher Phillips, Manfred Kayser, Walther Parson, Wojciech Branicki
Published in: International Journal of Legal Medicine, 135/6, 2021, Page(s) 2209-2219, ISSN 0937-9827
Publisher: Springer Verlag
DOI: 10.1007/s00414-021-02665-1

Development of the VISAGE enhanced tool and statistical models for epigenetic age estimation in blood, buccal cells and bones

Author(s): Anna Woźniak, Antonia Heidegger, Danuta Piniewska-Róg, Ewelina Pośpiech, Catarina Xavier, Aleksandra Pisarek, Ewa Kartasińska, Michał Boroń, Ana Freire-Aradas, Marta Wojtas, Maria de la Puente, Harald Niederstätter, Rafał Płoski, Magdalena Spólnicka, Manfred Kayser, Christopher Phillips, Walther Parson, Wojciech Branicki
Published in: Aging, 13/5, 2021, Page(s) 6459-6484, ISSN 1945-4589
Publisher: Albany
DOI: 10.18632/aging.202783

Recent progress, methods and perspectives in forensic epigenetics

Author(s): Athina Vidaki, Manfred Kayser
Published in: Forensic Science International: Genetics, 37, 2018, Page(s) 180-195, ISSN 1872-4973
Publisher: Elsevier BV
DOI: 10.1016/j.fsigen.2018.08.008

Development and inter-laboratory validation of the VISAGE enhanced tool for age estimation from semen using quantitative DNA methylation analysis

Author(s): A. Heidegger, A. Pisarek, M. de la Puente, H. Niederstätter, E. Pośpiech, A. Woźniak, N. Schury, M. Unterländer, M. Sidstedt, K. Junker, M. Ventayol Garcia, FX Laurent, A. Ulus, J. Vannier, I. Bastisch, J. Hedman, T. Sijen, W. Branicki, C. Xavier, W. Parson
Published in: Forensic Science International: Genetics, 56, 2022, Page(s) 102596, ISSN 1872-4973
Publisher: Elsevier BV
DOI: 10.1016/j.fsigen.2021.102596

Progress in the implementation of massively parallel sequencing for forensic genetics: results of a European-wide survey among professional users

Author(s): Theresa E. Gross, Jan Fleckhaus, Peter M. Schneider
Published in: International Journal of Legal Medicine, 135/4, 2021, Page(s) 1425-1432, ISSN 0937-9827
Publisher: Springer Verlag
DOI: 10.1007/s00414-021-02569-0

Non-peer reviewed articles (1)

Shifting Ethical Boundaries in Forensic Use of DNA.

Author(s): Gabrielle Samuel, Barbara Prainsack
Published in: Jahrbuch für Wissenschaft und Ethik, 24 (1), 2019, Page(s) 155-172, ISSN 1613-1142
Publisher: Walter de Gruyter
DOI: 10.1515/jwiet-2019-0007