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Effects of Nutrition and Lifestyle on Impulsive, Compulsive, and Externalizing behaviours

Deliverables

Manuscript 1: effects of dietary intake and lifestyle across lifespan stratified by sex and SES

The deliverable will contain a manuscript describing the association between dietary risk factors and lifestyle behavior related with maladaptive behavior.

Manuscript: Effect of nutrition, lifestyle, impulsivity, compulsivity on the brain (UK Biobank)

Using the UK biobank we will detect the small effects of dietary risk factors in impulsivity, compulsivity and addiction and brain variables (MRI derived). Results will be summarized in a manuscript.

Manuscript: Validation of selected epigenetically modified candidate genes derived from human cohorts profiling in the BALB/cJ and Tph2-modified mouse models

The deliverable will contain a manuscript addressing the identification of mechanistic pathways involved in epigenetic process for candidate genes derived from human cohorts using mouse models

Manuscript 4: how genetic contributions to impulsivity and compulsivity depend on dietary intake and lifestyle using twin modelling

The deliverable will contain a manuscript addressing the interaction analysis between candidate genespathways and dietary factors and their relation with maladaptive behavior using twin data

Manuscript 3: how lifestyle may enhance harmful/beneficial effects of diet or cancel these out

The deliverable will contain a manuscript describing the relationship between diet characteristics and lifestyle factors

Manuscript 5: offspring candidate gene pathways x maternal diet/lifestyle interactions during pregnancy on offspring impulsivity and compulsivity

The deliverable will contain a manuscript addressing threeway interaction analysis of genes and environment as predictors of maladaptive behavior

Manuscript 2: effects of dietary intake during pregnancy on offspring impulsivity and compulsivity

The deliverable will contain a manuscript describing the role of dietary factors in the pregnant mother as predictive factor of the child’s behavior.

Registration number of clinical studies in a WHO- or ICMJE- approved registry

Information pertinent to the registration of the RCTs to the proper entities & authorities.

Manuscript on the effect of early diet (birth to 2.5y) on microbiome composition and its relation with impulsive/compulsive behaviour

Age is crucial for microbiome development. The deliverable will contain a manuscript describing the effect that diet on early life has on early life behavior.

Manuscript: Epigenetically moderated candidate genes for impulsive/compulsive and addictive behaviour in selected human cohorts

We will identify candidate genes for brain measures MRI based and maladaptive behavior that are actively modified by epigenetic processes in human cohorts Results will be summarized in a manuscript

Manuscript: Effect of nutrition, lifestyle, microbiome and impulsivity, compulsivity on the brain (IMpACT)

The deliverable will contain a manuscript addressing the relation between key microbial communities in behavior accounting for age diet and PA in the IMpACT human cohorts

Learning Modules online on website

We will work with each WP to prepare the learning modules described in D4.03. Working with members of each WP we will create slide audiocasts describing each project for the website.

Go online of public project website, Eat2beNICE website internal part online

Corporate design and public part of Eat2BeNICE website set up to disseminate results to the public. Eat2BeNICE website internet for internal use and project monitoring

Publications

Cross-disorder genetic analyses implicate dopaminergic signaling as a biological link between Attention-Deficit/Hyperactivity Disorder and obesity measures

Author(s): Nina Roth Mota, Geert Poelmans, Marieke Klein, Bàrbara Torrico, Noèlia Fernàndez-Castillo, Bru Cormand, Andreas Reif, Barbara Franke, Alejandro Arias Vásquez
Published in: Neuropsychopharmacology, 45/7, 2020, Page(s) 1188-1195, ISSN 0893-133X
Publisher: Nature Publishing Group
DOI: 10.1038/s41386-019-0592-4

Genome-Wide DNA Methylation Patterns in Persistent Attention-Deficit/Hyperactivity Disorder and in Association With Impulsive and Callous Traits

Author(s): Mandy Meijer, Marieke Klein, Eilis Hannon, Dennis van der Meer, Catharina Hartman, Jaap Oosterlaan, Dirk Heslenfeld, Pieter J. Hoekstra, Jan Buitelaar, Jonathan Mill, Barbara Franke
Published in: Frontiers in Genetics, 11, 2020, ISSN 1664-8021
Publisher: Frontiers Media
DOI: 10.3389/fgene.2020.00016

Treating impulsivity with probiotics in adults (PROBIA): study protocol of a multicenter, double-blind, randomized, placebo-controlled trial

Author(s): Gara Arteaga-Henríquez, Silvia Karina Rosales-Ortiz, Alejandro Arias-Vásquez, Istvan Bitter, Ylva Ginsberg, Pol Ibañez-Jimenez, Tünde Kilencz, Catharina Lavebratt, Silke Matura, Andreas Reif, Janos Rethelyi, Vanesa Richarte, Nanda Rommelse, Anne Siegl, J. Antoni Ramos-Quiroga
Published in: Trials, 21/1, 2020, ISSN 1745-6215
Publisher: BioMed Central
DOI: 10.1186/s13063-019-4040-x

Genomic analysis of the natural history of attention-deficit/hyperactivity disorder using Neanderthal and ancient Homo sapiens samples

Author(s): Paula Esteller-Cucala, Iago Maceda, Anders D. Børglum, Ditte Demontis, Stephen V. Faraone, Bru Cormand, Oscar Lao
Published in: Scientific Reports, 10/1, 2020, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-020-65322-4

Attention-deficit/hyperactivity disorder and lifetime cannabis use: genetic overlap and causality

Author(s): María Soler Artigas, Cristina Sánchez-Mora, Paula Rovira, Vanesa Richarte, Iris Garcia-Martínez, Mireia Pagerols, Ditte Demontis, Sven Stringer, Jacqueline M. Vink, Anders D. Børglum, Benjamin M. Neale, Barbara Franke, Stephen V. Faraone, Miguel Casas, Josep Antoni Ramos-Quiroga, Marta Ribasés
Published in: Molecular Psychiatry, 25/10, 2020, Page(s) 2493-2503, ISSN 1359-4184
Publisher: Nature Publishing Group
DOI: 10.1038/s41380-018-0339-3

Gut microbiota signature in treatment-naïve attention-deficit/hyperactivity disorder

Author(s): Vanesa Richarte, Cristina Sánchez-Mora, Montserrat Corrales, Christian Fadeuilhe, Laura Vilar-Ribó, Lorena Arribas, Estela Garcia, Silvia Karina Rosales-Ortiz, Alejandro Arias-Vasquez, María Soler-Artigas, Marta Ribasés, Josep Antoni Ramos-Quiroga
Published in: Translational Psychiatry, 11/1, 2021, ISSN 2158-3188
Publisher: Nature Publishing Group
DOI: 10.1038/s41398-021-01504-6

Cortical and Subcortical Brain Volumes Partially Mediate the Association between Dietary Composition and Behavioral Disinhibition: A UK Biobank Study

Author(s): Daan van Rooij, Lizanne Schweren, Huiqing Shi, Catharina A Hartman, Jan K Buitelaar
Published in: Nutrients, 13/10, 2021, Page(s) 3542, ISSN 2072-6643
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/nu13103542

Epigenome-wide association study of attention-deficit/hyperactivity disorder in adults

Author(s): Paula Rovira, Cristina Sánchez-Mora, Mireia Pagerols, Vanesa Richarte, Montserrat Corrales, Christian Fadeuilhe, Laura Vilar-Ribó, Lorena Arribas, Gemma Shireby, Eilis Hannon, Jonathan Mill, Miquel Casas, Josep Antoni Ramos-Quiroga, María Soler Artigas, Marta Ribasés
Published in: Translational Psychiatry, 10/1, 2020, ISSN 2158-3188
Publisher: Nature Publishing Group
DOI: 10.1038/s41398-020-0860-4

Datasets

Additional file 3 of Studying dietary intake in daily life through multilevel two-part modelling: a novel analytical approach and its practical application

Author(s): Ruf, Alea; Neubauer, Andreas B.; Ebner-Priemer, Ulrich; Reif, Andreas; Matura, Silke
Published in: figshare

Additional file 2 of Studying dietary intake in daily life through multilevel two-part modelling: a novel analytical approach and its practical application

Author(s): Ruf, Alea; Neubauer, Andreas B.; Ebner-Priemer, Ulrich; Reif, Andreas; Matura, Silke
Published in: figshare