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Treating mitochondrial disease caused by pathogenic mtDNA mutations

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Mitochondrial fusion is required for regulation of mitochondrial DNA replication

Author(s): Eduardo Silva Ramos, Elisa Motori, Christian Brüser, Inge Kühl, Assa Yeroslaviz, Benedetta Ruzzenente, Johanna H. K. Kauppila, Jakob D. Busch, Kjell Hultenby, Bianca H. Habermann, Stefan Jakobs, Nils-Göran Larsson, Arnaud Mourier
Published in: PLOS Genetics, Issue 15/6, 2019, Page(s) e1008085, ISSN 1553-7404
DOI: 10.1371/journal.pgen.1008085

Modulation of mtDNA copy number ameliorates the pathological consequences of a heteroplasmic mtDNA mutation in the mouse

Author(s): R. Filograna, C. Koolmeister, M. Upadhyay, A. Pajak, P. Clemente, R. Wibom, M. L. Simard, A. Wredenberg, C. Freyer, J. B. Stewart, N. G. Larsson
Published in: Science Advances, Issue 5/4, 2019, Page(s) eaav9824, ISSN 2375-2548
DOI: 10.1126/sciadv.aav9824