Project description
Molecular scaffold for in vivo gene therapy applications
Most in vivo gene therapy applications make use of viral vectors that can efficiently deliver the gene(s) of interest inside target cells, mimicking the viral infection process. However, viral-mediated gene delivery suffers from safety issues, such as insertional mutagenesis, and necessitates alternative non viral approaches for delivering genes inside cells. The EU-funded ENDOSCAPE project proposes to employ molecules that facilitate escape from endosomes, the cell organelles responsible for trapping internalised molecules and leading them to degradation. The idea is to generate a molecular scaffold that encompasses these enhancers alongside the gene of interest and a targeting ligand, solving the problem of cytosolic and nucleic delivery of gene therapeutics.
Programme(s)
Funding Scheme
RIA - Research and Innovation actionCoordinator
10117 Berlin
Germany
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Participants (11)
3723 MB Bilthoven
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The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
80539 Munchen
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9052 Zwijnaarde - Gent
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14195 Berlin
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15782 Santiago De Compostela
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00133 Roma
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69730 Genay
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The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
80686 Munchen
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44121 Ferrara
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4051 Basel
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10117 Berlin
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The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.