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ENDOSCAPE, a clinically applicable non-viral gene delivery technology

Project description

Molecular scaffold for in vivo gene therapy applications

Most in vivo gene therapy applications make use of viral vectors that can efficiently deliver the gene(s) of interest inside target cells, mimicking the viral infection process. However, viral-mediated gene delivery suffers from safety issues, such as insertional mutagenesis, and necessitates alternative non viral approaches for delivering genes inside cells. The EU-funded ENDOSCAPE project proposes to employ molecules that facilitate escape from endosomes, the cell organelles responsible for trapping internalised molecules and leading them to degradation. The idea is to generate a molecular scaffold that encompasses these enhancers alongside the gene of interest and a targeting ligand, solving the problem of cytosolic and nucleic delivery of gene therapeutics.

Call for proposal

H2020-SC1-BHC-2018-2020

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Sub call

H2020-SC1-2018-Single-Stage-RTD

Coordinator

CHARITE - UNIVERSITAETSMEDIZIN BERLIN
Net EU contribution
€ 1 381 303,75
Address
Chariteplatz 1
10117 Berlin
Germany

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Region
Berlin Berlin Berlin
Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,00

Participants (11)

SAPREME TECHNOLOGIES BV
Netherlands
Net EU contribution
€ 799 160,00
Address
Professor Bronkhorstlaan 10 G 92
3723 MB Bilthoven

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
West-Nederland Utrecht Utrecht
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
€ 0,00
MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV
Germany
Net EU contribution
€ 671 878,75
Address
Hofgartenstrasse 8
80539 Munchen

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Region
Bayern Oberbayern München, Kreisfreie Stadt
Activity type
Research Organisations
Other funding
€ 0,00
VIB VZW
Belgium
Net EU contribution
€ 584 087,50
Address
Rijvisschestraat 120
9052 Zwijnaarde - Gent

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Region
Vlaams Gewest Prov. Oost-Vlaanderen Arr. Gent
Activity type
Research Organisations
Other funding
€ 0,00
FREIE UNIVERSITAET BERLIN
Germany
Net EU contribution
€ 429 000,00
Address
Kaiserswerther Strasse 16-18
14195 Berlin

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Region
Berlin Berlin Berlin
Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,00
UNIVERSIDAD DE SANTIAGO DE COMPOSTELA
Spain
Net EU contribution
€ 444 237,50
Address
Colexio De San Xerome Praza Do Obradoiro S/n
15782 Santiago De Compostela

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Region
Galicia A Coruña
Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,00
UNIVERSITA DEGLI STUDI DI ROMA TOR VERGATA
Italy
Net EU contribution
€ 407 500,00
Address
Via Cracovia 50
00133 Roma

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Region
Centro (IT) Lazio Roma
Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,00
EXTRASYNTHESE SAS
France
Net EU contribution
€ 472 500,00
Address
Impasse Jacquard Zi Lyon Nord
69730 Genay

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Auvergne-Rhône-Alpes Rhône-Alpes Rhône
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
€ 0,00
FRAUNHOFER GESELLSCHAFT ZUR FORDERUNG DER ANGEWANDTEN FORSCHUNG EV
Germany
Net EU contribution
€ 540 476,25
Address
Hansastrasse 27c
80686 Munchen

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Region
Bayern Oberbayern München, Kreisfreie Stadt
Activity type
Research Organisations
Other funding
€ 0,00
UNIVERSITA DEGLI STUDI DI FERRARA
Italy
Net EU contribution
€ 488 750,00
Address
Via Ariosto 35
44121 Ferrara

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Region
Nord-Est Emilia-Romagna Ferrara
Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,00
UNIVERSITAT BASEL
Switzerland
Net EU contribution
€ 261 750,00
Address
Petersplatz 1
4051 Basel

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Region
Schweiz/Suisse/Svizzera Nordwestschweiz Basel-Stadt
Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,00
TP21 GMBH
Germany
Net EU contribution
€ 370 000,00
Address
Luisenstrasse 14
10117 Berlin

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Berlin Berlin Berlin
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
€ 0,00