Staying young at heart – a lesson from zebrafish on epigenetic inheritance
Some animals, including zebrafish, have the incredible ability to regenerate their injured heart. Epigenetic remodeling may play a pivotal role in the process and the environment can also influence this capacity. Transgenerational epigenetic inheritance (TEI) is the transmission of experiences from parents to their offspring through the gametes, without alteration of the primary structure of DNA. Changes in DNA methylation, histone modifications and non-coding RNAs are associated with TEI. The EU-funded TransReg project studies the epigenetic inheritance of organ regeneration using the zebrafish model. The aim of the project is to assess whether cardiac injury causes epigenetic modifications in sperm and if offspring from injured parental fish display altered heart regeneration. The findings will elucidate the origins of cardiovascular disease and define epigenetic priming as a basis for regeneration.
Fields of science
Funding SchemeERC-COG - Consolidator Grant
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