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Transgenerational epigenetic inheritance of cardiac regenerative capacity in the zebrafish

Project description

Staying young at heart – a lesson from zebrafish on epigenetic inheritance

Some animals, including zebrafish, have the incredible ability to regenerate their injured heart. Epigenetic remodeling may play a pivotal role in the process and the environment can also influence this capacity. Transgenerational epigenetic inheritance (TEI) is the transmission of experiences from parents to their offspring through the gametes, without alteration of the primary structure of DNA. Changes in DNA methylation, histone modifications and non-coding RNAs are associated with TEI. The EU-funded TransReg project studies the epigenetic inheritance of organ regeneration using the zebrafish model. The aim of the project is to assess whether cardiac injury causes epigenetic modifications in sperm and if offspring from injured parental fish display altered heart regeneration. The findings will elucidate the origins of cardiovascular disease and define epigenetic priming as a basis for regeneration.

Host institution

UNIVERSITAET BERN
Net EU contribution
€ 1 672 875,00
Address
Hochschulstrasse 6
3012 Bern
Switzerland

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Region
Schweiz/Suisse/Svizzera Espace Mittelland Bern / Berne
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00

Beneficiaries (2)

UNIVERSITAET BERN
Switzerland
Net EU contribution
€ 1 672 875,00
Address
Hochschulstrasse 6
3012 Bern

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Region
Schweiz/Suisse/Svizzera Espace Mittelland Bern / Berne
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
CENTRO NACIONAL DE INVESTIGACIONES CARDIOVASCULARES CARLOS III (F.S.P.)
Spain
Net EU contribution
€ 326 250,00
Address
Calle Melchor Fernandez Almagro 3
28029 Madrid

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Region
Comunidad de Madrid Comunidad de Madrid Madrid
Activity type
Research Organisations
Non-EU contribution
€ 0,00