Medical microbots to support new assisted reproduction techniques

Project Information

MicroRepro

Grant agreement ID: 835268

DOI 10.3030/835268

EC signature date 25 June 2019

Start date 1 November 2019

End date 31 October 2025

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost € 2 496 141,00

EU contribution € 2 496 141,00

Coordinated by

TECHNISCHE UNIVERSITAET CHEMNITZ
Germany

Publications

Peer reviewed articles (18)

Human spermbots for patient-representative 3D ovarian cancer cell treatment

Author(s): Haifeng Xu, Mariana Medina-Sánchez, Wunan Zhang, Melanie P. H. Seaton, Daniel R. Brison, Richard J. Edmondson, Stephen S. Taylor, Louisa Nelson, Kang Zeng, Steven Bagley, Carla Ribeiro, Lina P. Restrepo, Elkin Lucena, Christine K. Schmidt, Oliver G. Schmidt
Published in: Nanoscale, Issue 12/39, 2020, Page(s) 20467-20481, ISSN 2040-3364
Publisher: Royal Society of Chemistry
DOI: 10.1039/d0nr04488a

Magnetic Micromotors for Multiple Motile Sperm Cells Capture, Transport, and Enzymatic Release

Author(s): Haifeng Xu, Mariana Medina‐Sánchez, Oliver G. Schmidt
Published in: Angewandte Chemie International Edition, Issue 59/35, 2020, Page(s) 15029-15037, ISSN 1433-7851
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/anie.202005657

Multifunctional 4D-printed sperm-hybrid microcarriers for assisted reproduction

Author(s): Fatemeh Rajabasadi, Silvia Moreno, Kristin Fichna, Azaam Aziz, Dietmar Appelhans, Oliver G. Schmidt, Mariana Medina-Sánchez
Published in: Advanced Materials, Issue 34/50, 2022, ISSN 0935-9648
Publisher: United Nations Industrial Developement Organization
DOI: 10.1002/adma.202204257

IRONSperm: Sperm-templated soft magnetic microrobots

Author(s): Veronika Magdanz; Islam S. M. Khalil; Juliane Simmchen; Guilherme Phillips Furtado; Sumit Mohanty; Johannes Gebauer; Haifeng Xu; Anke Klingner; Azaam Aziz; Mariana Medina-Sánchez; Oliver G. Schmidt; Oliver G. Schmidt; Oliver G. Schmidt; Sarthak Misra; Sarthak Misra
Published in: Science Advances, Issue 6/28, 2020, Page(s) eaba5855, ISSN 2375-2548
Publisher: American Association for the Advancement of Science
DOI: 10.1126/sciadv.aba5855

Micromotor-mediated sperm constrictions for improved swimming performance

Author(s): Friedrich Striggow, Lidiia Nadporozhskaia, Benjamin M. Friedrich, Oliver G. Schmidt, Mariana Medina-Sánchez
Published in: The European Physical Journal E, Issue 44/5, 2021, ISSN 1292-8941
Publisher: Springer Verlag
DOI: 10.1140/epje/s10189-021-00050-9

Dual Ultrasound and Photoacoustic Tracking of Magnetically Driven Micromotors: From In Vitro to In Vivo

Author(s): Azaam Aziz, Joost Holthof, Sandra Meyer, Oliver G. Schmidt, Mariana Medina-Sánchez
Published in: Advanced Healthcare Materials, Issue 10/22, 2021, Page(s) 2101077, ISSN 2192-2659
Publisher: World Scientific
DOI: 10.1002/adhm.202101077

Switching Propulsion Mechanisms of Tubular Catalytic Micromotors

Author(s): Paul Wrede, Mariana Medina‐Sánchez, Vladimir M. Fomin, Oliver G. Schmidt
Published in: Small, Issue 17/12, 2021, Page(s) 2006449, ISSN 1613-6810
Publisher: Wiley - V C H Verlag GmbbH & Co.
DOI: 10.1002/smll.202006449

Nanomaterial-decorated micromotors for enhanced photoacoustic imaging

Author(s): Azaam Aziz, Richard Nauber, Ana Sánchez Iglesias, Min Tang, Libo Ma, Luis M. Liz-Marzán, Oliver G. Schmidt, Mariana Medina-Sánchez
Published in: Journal of Micro-Bio Robotics, Issue 22. April 2023, 2023, ISSN 2194-6418
Publisher: Springer Science + Business Media
DOI: 10.1007/s12213-023-00156-7

Medical Imaging of Microrobots: Toward In Vivo Applications

Author(s): Azaam Aziz, Stefano Pane, Veronica Iacovacci, Nektarios Koukourakis, Jürgen Czarske, Arianna Menciassi, Mariana Medina-Sánchez, Oliver G. Schmidt
Published in: ACS Nano, Issue 14/9, 2020, Page(s) 10865-10893, ISSN 1936-0851
Publisher: American Chemical Society
DOI: 10.1021/acsnano.0c05530

Real-Time Optoacoustic Tracking of Single Moving Micro-objects in Deep Phantom and Ex Vivo Tissues

Author(s): Azaam Aziz, Mariana Medina-Sánchez, Jing Claussen, Oliver G. Schmidt
Published in: Nano Letters, Issue 19/9, 2019, Page(s) 6612-6620, ISSN 1530-6984
Publisher: American Chemical Society
DOI: 10.1021/acs.nanolett.9b02869

Sperm-hybrid micromotors: on-board assistance for nature's bustling swimmers

Author(s): Lukas Schwarz, Mariana Medina-Sanchez, Oliver G. Schmidt
Published in: Reproduction, 2019, ISSN 1470-1626
Publisher: Society for Reproduction and Fertility
DOI: 10.1530/rep-19-0096

Real‐Time IR Tracking of Single Reflective Micromotors through Scattering Tissues

Author(s): Azaam Aziz, Mariana Medina‐Sánchez, Nektarios Koukourakis, Jiawei Wang, Robert Kuschmierz, Hannes Radner, Jürgen W. Czarske, Oliver G. Schmidt
Published in: Advanced Functional Materials, 2019, Page(s) 1905272, ISSN 1616-301X
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/adfm.201905272

Sperm‐Driven Micromotors Moving in Oviduct Fluid and Viscoelastic Media

Author(s): Friedrich Striggow, Mariana Medina‐Sánchez, Günter K. Auernhammer, Veronika Magdanz, Benjamin M. Friedrich, Oliver G. Schmidt
Published in: Small, Issue 16/24, 2020, Page(s) 2000213, ISSN 1613-6810
Publisher: Wiley - V C H Verlag GmbbH & Co.
DOI: 10.1002/smll.202000213

Shape-Controlled Flexible Microelectronics Facilitated by Integrated Sensors and Conductive Polymer Actuators

Author(s): Boris Rivkin, Christian Becker, Farzin Akbar, Rachappa Ravishankar, Dmitriy D. Karnaushenko, Ronald Naumann, Alaleh Mirhajivarzaneh, Mariana Medina-Sánchez, Daniil Karnaushenko, Oliver G. Schmidt
Published in: Advanced Intelligent Systems, Issue 3/6, 2021, Page(s) 2000238, ISSN 2640-4567
Publisher: Wiley
DOI: 10.1002/aisy.202000238

Sperm Micromotors for Cargo Delivery through Flowing Blood

Author(s): Haifeng Xu, Mariana Medina-Sánchez, Manfred F. Maitz, Carsten Werner, Oliver G. Schmidt
Published in: ACS Nano, Issue 14/3, 2020, Page(s) 2982-2993, ISSN 1936-0851
Publisher: American Chemical Society
DOI: 10.1021/acsnano.9b07851

3D and 4D lithography of untethered microrobots

Author(s): Fatemeh Rajabasadi, Lukas Schwarz, Mariana Medina-Sánchez, Oliver G. Schmidt
Published in: Progress in Materials Science, Issue 120, 2021, Page(s) 100808, ISSN 0079-6425
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.pmatsci.2021.100808

Engineering microrobots for targeted cancer therapies from a medical perspective

Author(s): Christine K. Schmidt, Mariana Medina-Sánchez, Richard J. Edmondson, Oliver G. Schmidt
Published in: Nature Communications, Issue 11, 2020, Page(s) 5618, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-020-19322-7

A Rotating Spiral Micromotor for Noninvasive Zygote Transfer

Author(s): Lukas Schwarz, Dmitriy D. Karnaushenko, Franziska Hebenstreit, Ronald Naumann, Oliver G. Schmidt, Mariana Medina‐Sánchez
Published in: Advanced Science, Issue 7/18, 2020, Page(s) 2000843, ISSN 2198-3844
Publisher: WILEY-VCH
DOI: 10.1002/advs.202000843

Other (1)

In vivo imaging of swimming micromotors using hybrid high-frequency ultrasound and photoacoustic imaging

Author(s): Azaam Aziz, Joost Holthof, Sandra Meyer, Oliver G. Schmidt, Mariana Medina-Sánchez
Published in: 2020
Publisher: bioRXiv
DOI: 10.11016.15.148791/2020.06.15.148791