Objetivo Neurochemical, behavioural and electroencephalographical correlates of seizure activity (of convulsive and non-convulsive types) will be studied in KM, Wistar and WAG/Rij rat strains, while modifying the brain histaminergic, dopaminergic, and GABAergic systems. The modulation of three receptor systems is an opportunity to develop functional (physiological, anatomical) models for the interaction between these receptor systems. The resulted experimental data will form a basis for systemic, multi-approached analysis, intended to yield fundamental new knowledge on the basic brain mechanisms, as well as new targets for pharmaceutical approaches. Comparison of convulsive, non-convulsive and mixed animal models of epilepsies permits the identification of the critical features from a variety of observed parameters. The specially designed software will evaluate the non-stationary character of epileptic dynamic and most of the pharmacological effects. Additionally, three-component mathematical model of ensembles of neuron-like elements will be used to simulate the neurophysiological experiments.The proposed project involves 5 teams (2 INTAS member teams, and 3 NIS teams), which are actively working in the fields of pharmacology (Department of Pharmacology and Toxicology of University of Kuopio, Finland; Nijmegen Institute for Cognition and Information, Catholic University of Nijmegen, the Netherlands; Institute of Pharmacology of Russian Academy of Medical Sciences, Russian Federation), neurophysiology and electrophysiology (Institute of Higher Nervous Activity and Neurophysiology of Russian Academy of Sciences, Moscow, Russian Federation; Nijmegen Institute for Cognition and Information, Catholic University of Nijmegen, the Netherlands) and computer sciences and neuronal networks (Institute of Applied Physics of Russian Academy of Sciences, Nijni Novgorod, Russian Federation). Some of the participating teams have significant experience of collaboration other ones have just started with joint research or exchange of ideas. This should result in quick start with the planned experiments and mutual interest of the participating teams in multi-faceted approach.In summary, it is hoped that the proposed project will revile actual disturbances in these neurotransmitter system in the living brain. We do realise that the development of such physiological models will neither be easy nor straight forward, however, the potential benefit of such physiological models will be invaluable for providing an insight into how the brain actually functions. Programa(s) IC-INTAS - International Association for the promotion of cooperation with scientists from the independent states of the former Soviet Union (INTAS), 1993- Tema(s) 4 - Life Sciences OPEN - OPEN Call Convocatoria de propuestas Data not available Régimen de financiación Data not available Coordinador University of Kuopio Aportación de la UE Sin datos Dirección Harjulantie 1 70211 Kuopio Finlandia Ver en el mapa Coste total Sin datos Participantes (4) Ordenar alfabéticamente Ordenar por aportación de la UE Ampliar todo Contraer todo Academy of Medical Sciences Rusia Aportación de la UE Sin datos Dirección Baltiyskaya Street, 8 125315 Moscow Ver en el mapa Coste total Sin datos Catholic University of Nijmegen Países Bajos Aportación de la UE Sin datos Dirección Montessorilaan 3 6500 HE Nijmegen Ver en el mapa Coste total Sin datos Russian Academy of Sciences Rusia Aportación de la UE Sin datos Dirección Butlerova str, 5A 117485 Moscow Ver en el mapa Coste total Sin datos Russian Academy of Sciences Rusia Aportación de la UE Sin datos Dirección Ul'yanova str., 46 603600 Nizhny Novgorod Ver en el mapa Coste total Sin datos
