Objetivo Cytotoxic T-lymphocytes will be a primary effector in any successful HIV-1 vaccine. Knowledge of the protective CTL epitopes and their cross-subtype effectiveness is incomplete. The study proposes to use the setting of natural infection in individuals multiply exposed to HIV subtypes A, C, and D to gain understanding of a protective CTL response. From a high-risk cohort in Tanzania 3 groups will be identified: persistently seronegative, persistently infected with a single HIV subtype or recombinant, and super infected with a second subtype. CTL ELISPOT and epitope mapping, viral load and diversity, HLA typing, and MHA, a new sub-typing tool, will be employed. This study will be the first to define the CTL response capable of protecting from new HIV infections in persistent seronegatives and, in the same population and setting, to identify the flawed CTL responses that permit super infection of already infected individuals. Ámbito científico medical and health scienceshealth sciencesinfectious diseasesRNA virusesHIVmedical and health sciencesbasic medicinepharmacology and pharmacypharmaceutical drugsvaccines Programa(s) FP5-INCO 2 - Programme for research, technological development and demonstration on "Confirming the international role of Community research,1998-2002" Tema(s) 1.2.1.-1.4. - Research for development Convocatoria de propuestas Data not available Régimen de financiación CSC - Cost-sharing contracts Coordinador LUDWIG-MAXIMILIANS UNIVERSITY OF MUNICH Aportación de la UE Sin datos Dirección 5,Leopoldstrasse 5 80802 MUENCHEN Alemania Ver en el mapa Coste total Sin datos Participantes (4) Ordenar alfabéticamente Ordenar por aportación de la UE Ampliar todo Contraer todo NATIONAL INSTITUTE FOR COMMUNICABLE DISEASES Sudáfrica Aportación de la UE Sin datos Dirección 2131 JOHANNESBURG Ver en el mapa Coste total Sin datos NATIONAL PUBLIC HEALTH INSTITUTE Finlandia Aportación de la UE Sin datos Dirección Mannerheimintie 16 00300 HELSINKI Ver en el mapa Coste total Sin datos REGIONAL MEDICAL OFFICE OF THE MINISTRY OF HEALTH OF TANZANIA Tanzania Aportación de la UE Sin datos Dirección MBEYA Ver en el mapa Coste total Sin datos UNIVERSITY OF CAPE TOWN Sudáfrica Aportación de la UE Sin datos Dirección Anzio Road 7925 OBSERVATORY, CAPE TOWN Ver en el mapa Coste total Sin datos
