Objective
Antibiotics resistance of pathogens is a major threat to public health and safety. The rapid spread of resistant strains increases the risk of epidemics. This issue also includes preparedness to deal with bio-terrorism. The objectives of the ET-PA project are to develop an open, generic platform to enable the development of new classes of protein-antibiotics. The key technology (REPPs) is based on a principle that is proprietary to one of the participating SMEs, consisting of rationally modified class II restriction enzymes (RE) fused to cell penetration peptide sequences (PP) that selectively allow microbial cell penetration. Introduction of a REPP system into pathogens would lead to effective cell killing. The REPP will be designed to inactivate major microbial pathogens, i.e. S. aureus, P. aeruginosa and C. Albicans. Addressing these ambitious objectives will require a Co-operative Research setup with complementing expertise and resources, coming both from high-tech SMEs and expert academic RTD partners. The ET-PA project will be divided into four work packages:
1.Discovery -The design of a technology platform for the discovery of PP sequences for proper function in antibiotic REPP constructs.
2.Characterization -extensive characterization of the biological activity of antibiotic REPP constructs.
3.Technological platform - configuration of a semi-automatic and embedding technology platform that enables a coherent and unified approach for a rapid translation of REPP components into protein antibiotics.
4.Management - to assure, consolidation and coordination of the ET-PA project, support and protection of Intellectual Property, and contacts to subsequently license the outcomes to a third-party end-user.
The commitment and collective efforts of all participants is the best warranty for a success of the ET-PA project that will provide a technology platform to translate the most effective horizontal bacterial defence system into innovative medicine.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences health sciences public health
- natural sciences biological sciences biochemistry biomolecules proteins proteomics
- medical and health sciences basic medicine pharmacology and pharmacy pharmaceutical drugs antibiotics
- medical and health sciences basic medicine pharmacology and pharmacy drug resistance antibiotic resistance
- natural sciences biological sciences biochemistry biomolecules proteins enzymes
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2003-SME-1
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Data not available
Coordinator
TRIESTE
Italy
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.