Objetivo Dynamic Combinatorial Chemistry is proving to be a powerful tool in the search for new host-guest systems. A dynamic combinatorial library consists of a mixture of compounds made by connecting building blocks through reversible covalent linkages. Addition of a template (host or guest) shifts the equilibrium in favour of a strongly binding partner at the expense of other library members. By this means a very large number of compounds are screened, and simple analytical techniques can determine suitable matc hes for the template. In the case where the template is a transition state analogue for a given reaction the host(s) produced would be expected to act as catalysts (transistion state stabilization). In this way the system itself selects the potential cata lysts and drives their synthesis. This will be exploited in the proposed research, where catalysts will be sought out through selection based methods, starting with ester hydrolysis and advancing to asymmetric catalysis and peptide cleavage. Ámbito científico natural sciencesbiological sciencesbiochemistrybiomoleculesnatural scienceschemical sciencescatalysisnatural scienceschemical sciencesorganic chemistryamines Palabras clave host guest chemistry supramolecular chemistry thermodynamic control Programa(s) FP6-MOBILITY - Human resources and Mobility in the specific programme for research, technological development and demonstration "Structuring the European Research Area" under the Sixth Framework Programme 2002-2006 Tema(s) MOBILITY-2.1 - Marie Curie Intra-European Fellowships (EIF) Convocatoria de propuestas FP6-2004-MOBILITY-5 Consulte otros proyectos de esta convocatoria Régimen de financiación EIF - Marie Curie actions-Intra-European Fellowships Coordinador THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE Aportación de la UE Sin datos Dirección The Old Schools, Trinity Lane CAMBRIDGE Reino Unido Ver en el mapa Enlaces Sitio web Opens in new window Coste total Sin datos
