Objetivo The MAP-kinase pathway is a major pathway in relaying signals from the plasma membrane into the nucleus. Its comprehensive understanding is needed for rational anti-cancer therapies.SIMAP will develop a comprehensive and robust simulation model of the pathway; populating it with kinetic parameters extracted from the literature and experimental work; simulating various types of inputs into the model; creating qualitative predictions and verifying them with independent experimentations. The model will integrate and analyse data from various types of resources vertically ranging from single molecule information, pathway modelling, up to clinical data and patient's response. SIMAP pioneers the integration of clinical phenotype into this improved biochemical model. Such multi-scale modelling has never been done in the field of Systems Biology and is a step forward.Combining generic mechanistic modelling of the biochemical behaviour, accompanied by new generic mining techniques and clinical data integration, will create a multidisciplinary platform prototype suitable for modelling of other cancer related pathways.Our approach will enable hypothesis-driven research aimed at the establishment of system level computational platforms available for various pharmaceutical applications. The concepts and methods we will develop will lead to the design of new therapeutic drugs, decrease the attrition rate of new drugs and make it possible to select patients on the basis of individual parameters of disease. Modelling-driven predictions regarding the impact of drug combinations will permit us to dramatically improve the design of pre-clinical and clinical trials, enhance patient response and limit adverse effects. Eventually this will optimise Public Health resources leading to significant pharmacoeconomic benefit.The project is lead by a drug and diagnostic discovery SME and an interdisciplinary industrial and academic leading teams of investigators. Ámbito científico medical and health scienceshealth sciencespublic healthmedical and health sciencesclinical medicineoncology Programa(s) FP6-IST - Information Society Technologies: thematic priority under the specific programme "Integrating and strengthening the European research area" (2002-2006). Tema(s) IST-2004-2.4.11 - Integrated biomedical information for better health Convocatoria de propuestas Data not available Régimen de financiación STREP - Specific Targeted Research Project Coordinador COMPUGEN LTD Aportación de la UE Sin datos Dirección PINCHAS ROSEN STREET 72 69512 TEL-AVIV Israel Ver en el mapa Coste total Sin datos Participantes (8) Ordenar alfabéticamente Ordenar por aportación de la UE Ampliar todo Contraer todo AUREUS PHARMA SA Francia Aportación de la UE Sin datos Dirección QUAI DE JEMMAPES 174 75010 PARIS 10 Ver en el mapa Coste total Sin datos CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS España Aportación de la UE Sin datos Dirección Calle Serrano 117 MADRID Ver en el mapa Enlaces Sitio web Opens in new window Coste total Sin datos FUNDACIO INSTITUT DE RECERCA DE L'HOSPITAL UNIVERSITARI VALL D'HEBRON España Aportación de la UE Sin datos Dirección PASSEIG VALL D HEBRON 119-129 08035 BARCELONA Ver en el mapa Coste total Sin datos HALEVI DWECK & CO. ARTTIC ISRAEL COMPANY LTD Israel Aportación de la UE Sin datos Dirección 54 HANEVIIM ST. JERUSALEM Ver en el mapa Enlaces Sitio web Opens in new window Coste total Sin datos ISTITUTO NAZIONALE PER LO STUDIO E LA CURA DEI TUMORI Italia Aportación de la UE Sin datos Dirección VIA GIACOMO VENEZIAN 1 20133 MILANO Ver en el mapa Coste total Sin datos MAX PLANCK GESELLSCHAFT ZUR FOERDERUNG DER WISSENSCHAFTEN E.V. Alemania Aportación de la UE Sin datos Dirección Hofgartenstrasse 8 MUENCHEN Ver en el mapa Enlaces Sitio web Opens in new window Coste total Sin datos THE UNIVERSITY OF GLASGOW Reino Unido Aportación de la UE Sin datos Dirección UNIVERSITY AVENUE G12 8QQ GLASGOW Ver en el mapa Coste total Sin datos THE WEIZMANN INSTITUTE OF SCIENCE Israel Aportación de la UE Sin datos Dirección HERZEL STREET 2 76100 REHOVOT Ver en el mapa Coste total Sin datos
