Objectif The TIM-barrel fold is the most widely found in nature, making up about 6% of the structures in the Protein Data Bank, and has been found in nature to catalyse reactions from five of the six EC classes. These facts all indicate the extraordinary capacity of the TIM-barrel as a reaction container, and suggest that it may be a versatile starting scaffold into which new catalytic capability can be engineered. In this research programme we will use directed evolution approaches, including state-of-the-art gene shuffling techniques developed in the Hollfelder lab at the University of Cambridge to tengineer novel catalytic function into a TIM-barrel scaffold. Champ scientifique natural sciencesbiological sciencesbiochemistrybiomoleculesproteins Programme(s) FP7-PEOPLE - Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Thème(s) FP7-PEOPLE-2009-IIF - Marie Curie Action: "International Incoming Fellowships" Appel à propositions FP7-PEOPLE-2009-IIF Voir d’autres projets de cet appel Régime de financement MC-IIF - International Incoming Fellowships (IIF) Coordinateur THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE Contribution de l’UE € 174 240,80 Adresse TRINITY LANE THE OLD SCHOOLS CB2 1TN Cambridge Royaume-Uni Voir sur la carte Région East of England East Anglia Cambridgeshire CC Type d’activité Higher or Secondary Education Establishments Contact administratif Keith Cann (Mr.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée
