Objective Chronic inflammatory diseases associated with allergy, including asthma and rhinitis, constitute a major and continuously growing public health concern for Europe. However, the causative factors and mechanisms converting a physiological inflammatory reaction to a chronic response triggering allergic disease remain elusive.Viral infections, particularly those caused by human rhinoviruses (RV) are the most frequent triggers of acute asthma exacerbations. RV infections have more recently been associated with asthma initiation; there is evidence suggesting that such infections may also contribute to respiratory allergy persistence.The strategic aims of PreDicta are to evaluate the hypothesis that repeated infections reprogram the immune system towards a persistent inflammatory pattern leading to respiratory allergies by (i) dissecting the molecular and cellular mechanisms involved in the lack of resolution of inflammation in the context of a human disease, (ii) identifying specific infectious agents and underlying altered host-pathogen interactions, and develop relevant prognostic and therapeutic strategies. PreDicta follows three interconnected workflows: models, mechanisms and translational output. Models include a longitudinal cohort in children, mouse models of repeated virus infection, primary epithelial cultures from patients, viral-bacterial interaction models, and models of epithelial-T-cell-dendritic cell interactions. These will be used to look into disease persistence, inflammation patterns, dysbiosis, immune regulation and resolution of inflammation. Translational outputs include prognostic use of subtype-specific antiviral antibodies, DNAZymes for therapeutic use and delivery technologies targeted to the bronchial epithelium.This interdisciplinary Consortium with strong track record, unique resources and strong translational focus, aims to produce new knowledge and technologies that can rapidly and effectively reach clinical care. Fields of science medical and health scienceshealth sciencespublic healthmedical and health sciencesclinical medicinepneumologyasthmamedical and health scienceshealth sciencesinflammatory diseasesmedical and health sciencesbasic medicineimmunologymedical and health sciencesclinical medicineallergology Programme(s) FP7-HEALTH - Specific Programme "Cooperation": Health Topic(s) HEALTH.2010.2.4.5-2 - Infection and dysbiosis as the triggers of the development of inflammatory processes in allergies and autoimmune diseases. FP7-HEALTH-2010-single-stage Call for proposal FP7-HEALTH-2010-single-stage See other projects for this call Funding Scheme CP-FP - Small or medium-scale focused research project Coordinator ETHNIKO KAI KAPODISTRIAKO PANEPISTIMIO ATHINON EU contribution € 560 077,00 Address 6 CHRISTOU LADA STR 10561 Athina Greece See on map Region Αττική Aττική Κεντρικός Τομέας Αθηνών Activity type Higher or Secondary Education Establishments Administrative Contact Efstathia Kafentzi (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data Participants (12) Sort alphabetically Sort by EU Contribution Expand all Collapse all IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE United Kingdom EU contribution € 1 080 780,00 Address SOUTH KENSINGTON CAMPUS EXHIBITION ROAD SW7 2AZ LONDON See on map Region London Inner London — West Westminster Activity type Higher or Secondary Education Establishments Administrative Contact Tatjana Palalic (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data MEDIZINISCHE UNIVERSITAET WIEN Austria EU contribution € 644 400,00 Address SPITALGASSE 23 1090 Wien See on map Region Ostösterreich Wien Wien Activity type Higher or Secondary Education Establishments Administrative Contact Rudolf Valenta (Prof.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data SCHWEIZERISCHES FORSCHUNGSINSTITUT FUER HOCHGEBIRGSKLIMA UND MEDIZIN IN DAVOS Switzerland EU contribution € 640 955,00 Address OBERE STRASSE 22 7270 Davos Platz See on map Region Schweiz/Suisse/Svizzera Ostschweiz Graubünden / Grigioni / Grischun Activity type Research Organisations Administrative Contact Daniela Bert (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data IDRYMA IATROVIOLOGIKON EREUNON AKADEMIAS ATHINON Greece EU contribution € 582 972,00 Address SORANOU EFESIOU 4 115 27 Athina See on map Region Αττική Aττική Κεντρικός Τομέας Αθηνών Activity type Research Organisations Administrative Contact Dimitris Raptis (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data UNIVERSYTET MEDYCZNY W LODZI. Poland EU contribution € 249 910,00 Address Al. Kosciuszki, 4 90419 Lodz See on map Region Makroregion centralny Łódzkie Łódzki Activity type Higher or Secondary Education Establishments Administrative Contact Aneta Andrzejczyk (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data UNIVERSITEIT GENT Belgium EU contribution € 589 020,00 Address SINT PIETERSNIEUWSTRAAT 25 9000 Gent See on map Region Vlaams Gewest Prov. Oost-Vlaanderen Arr. Gent Activity type Higher or Secondary Education Establishments Administrative Contact Nathalie Vandepitte (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data PHILIPPS UNIVERSITAET MARBURG Germany EU contribution € 489 180,00 Address BIEGENSTRASSE 10 35037 Marburg See on map Region Hessen Gießen Marburg-Biedenkopf Activity type Higher or Secondary Education Establishments Administrative Contact Christian Maarten Veldman (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data TURUN YLIOPISTO Finland EU contribution € 210 420,00 Address YLIOPISTONMAKI 20014 Turku See on map Region Manner-Suomi Etelä-Suomi Varsinais-Suomi Activity type Higher or Secondary Education Establishments Administrative Contact Eliisa Särkilahti (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data UNIVERSITATSKLINIKUM ERLANGEN Germany EU contribution € 403 676,00 Address MAXIMILIANSPLATZ 2 91054 Erlangen See on map Region Bayern Mittelfranken Erlangen, Kreisfreie Stadt Activity type Higher or Secondary Education Establishments Administrative Contact Ulrike Herrmann (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data BIOMAY AG Austria EU contribution € 77 250,00 Address LAZARETTGASSE 19 1090 WIEN See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Angela Neubauer (Dr.) Links Contact the organisation Opens in new window Total cost No data INSERM TRANSFERT SA France EU contribution € 300 000,00 Address 10 RUE D'ORADOUR-SUR-GLANE - PARISANTE CAMPUS 75015 PARIS See on map Region Ile-de-France Ile-de-France Paris Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Louis Jammayrac (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data VARSINAIS-SUOMEN SAIRAANHOITOPIIRIN KUNTAYHTYMA Finland EU contribution € 162 960,00 Address KIINAMYLLYNKATU 4-8 20520 Turku See on map Region Manner-Suomi Etelä-Suomi Varsinais-Suomi Activity type Research Organisations Administrative Contact Jari-Pekka Tuominen (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data