Objectif Severe spinal cord injury (SCI) permanently abolishes motor functions caudal to the lesion. Various strategies have beenpursued to promote functional recovery after such injuries. However, none of these attempts were able to return voluntarymovements in paralyzed subjects. Here, we propose an innovative transdisciplinary research program including parallelapproaches that will converge into an integrated multi-pronged therapy able to restore voluntary movements after paralyzingSCI. To achieve this goal, we will capitalize on our recent breakthroughs that demonstrate the impressive capacity ofpharmacological and electrical spinal cord stimulations to promote full weight bearing walking in paralyzed rats whencombined with rehabilitation. In Walk Again, we will improve high level control of spinal circuits with synergistic combinationsof pharmacological agents, and with the design of multisite stimulation strategies using electrode arrays. Functional electricalstimulation of muscles will provide complementary low level tuning capacities to adjust limb motion. To allow voluntary control,we will establish a new line of research and pioneer brain-spinal interfaces by which cortical modulations will directly adjuststimulations of spinal circuits and muscles. In the final stages, we will enable neurorehabilitation with this cortico-spinalneuroprosthesis in the presence of anti-NogoA regenerative therapy. The underlying objective is to devise a fully-operativeneuroprosthetic system that will enable self-driven rehabilitation in a permissive plastic environment. Walk Again will fertilizefrontier research with pioneer ideas that will increase European competitiveness while paving the way toward viable clinicalapplications to restore function in paralyzed individuals. Champ scientifique medical and health sciencesclinical medicinephysiotherapy Programme(s) FP7-IDEAS-ERC - Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Thème(s) ERC-SG-LS5 - ERC Starting Grant - Neurosciences and neural disorders Appel à propositions ERC-2010-StG_20091118 Voir d’autres projets de cet appel Régime de financement ERC-SG - ERC Starting Grant Institution d’accueil ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE Contribution de l’UE € 1 163 781,00 Adresse BATIMENT CE 3316 STATION 1 1015 Lausanne Suisse Voir sur la carte Région Schweiz/Suisse/Svizzera Région lémanique Vaud Type d’activité Higher or Secondary Education Establishments Contact administratif Caroline Vandevyver (Ms.) Chercheur principal Grégoire Richard Courtine (Prof.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée Bénéficiaires (2) Trier par ordre alphabétique Trier par contribution de l’UE Tout développer Tout réduire ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE Suisse Contribution de l’UE € 1 163 781,00 Adresse BATIMENT CE 3316 STATION 1 1015 Lausanne Voir sur la carte Région Schweiz/Suisse/Svizzera Région lémanique Vaud Type d’activité Higher or Secondary Education Establishments Contact administratif Caroline Vandevyver (Ms.) Chercheur principal Grégoire Richard Courtine (Prof.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée University of Zurich Participation terminée Suisse Contribution de l’UE € 231 759,00 Adresse RAMISTRASSE 71 8006 ZURICH Voir sur la carte Type d’activité Higher or Secondary Education Establishments Contact administratif Grégoire Richard Courtine (Prof.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée
