Objective
The aim of this study is to investigate the role of the neurotransmitter histamine in sensory and cognitive deficits (e.g. hearing voices, disturbed thinking and planning, memory problems) as they are observed in patients suffering from schizophrenia. The ideal location to conduct the study and to obtain a unique learning experience is at the Institute of Psychiatry, London United Kingdom, where staff comprises a mix of leading experts in the field of schizophrenia and experimental drug treatment as well as specialists in Magnetic Resonance Brain Imaging. The pharmacological treatment of psychotic symptoms including sensory and cognitive deficits as seen in schizophrenia remains partially unsuccessful due to side effects and treatment resistance. Therefore, new treatments are continuously developed by pharmaceutical companies. The neurotransmitter histamine is a promising target for new drugs. Histamine turnover in the brain has been suggested to be increased in schizophrenia which may underlie the positive symptoms. A decrease in histaminergic activity in the frontal cortex has been suggested to underlie the cognitive deficits. No attempts have been made until now to investigate the specific role of histamine in sensory and cognitive deficits typically seen in schizophrenics. To investigate this, I will assess the effects of increased histaminergic activity, by blocking the H3 receptor in healthy volunteers, on sensory gating and tasks of executive functioning (planning) and memory. Altered performance on such tasks would support the importance of histamine in schizophrenia and provides a model for new drug development in order to treat the sensory and cognitive deficits.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences basic medicine pharmacology and pharmacy drug discovery
- medical and health sciences clinical medicine psychiatry schizophrenia
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2009-IEF
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
WC2R 2LS London
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.