In vivo biology of the mononuclear phagocyte system. A molecular & functional approach

Objective

Leucocytes are hemopoietic cells involved in tissue homeostasis, inflammation, and the defence against infection. Recent efforts have focused on the innate immune system , responsible for the early defence against pathogens, at the cost of tissue inflammation and inflammatory disease. New tools and experimental strategies have allowed investigation of an essential component of the innate immune system: cells referred to as the mononuclear phagocyte system (MPS), which includes blood monocytes, tissue macrophages, and dendritic cells.
In a project supported by an Euryi award in France, we identified bone marrow progenitors for the MPS (Fogg et al., Science 2006), and a surprising exception to this rule: the existence of non-bone marrow precursors for tissue-resident cells (Chorro et al., J. Exp. Med 2009 in press), and in vivo functions of blood monocytes using intravital microscopy (Auffray et al., Science 2007). In 2008 I moved to London to start a new laboratory and benefit from a multidisciplinary environment, but I was not allowed to transfer my EURyi funding.
This new project build on our early discoveries, and aims to bring to the next stage the molecular analysis of monocyte/macrophage functions in an intact animal. Toward this aim we will therefore use a direct in vivo approach based on innovative mouse models and cutting edge microscopy techniques, to i) characterise the molecular control of homeostasis of a subset of resident cells of the MPS, the Langerhans cells, which are independent from the bone marrow, under steady state and inflammatory conditions, and investigate whether this model apply to other resident cells . We will also characterise the ii) functional outcomes and iii) the molecular mechanisms of tissue surveillance by blood monocytes during vascular inflammation in vivo by developing and employing cutting-edge imaging methods.

Fields of science (EuroSciVoc)

CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.

• medical and health sciences health sciences inflammatory diseases
• natural sciences physical sciences optics microscopy
• medical and health sciences basic medicine immunology
• medical and health sciences basic medicine physiology homeostasis

Programme(s)

Multi-annual funding programmes that define the EU’s priorities for research and innovation.

• FP7-IDEAS-ERC - Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)

Topic(s)

Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.

• ERC-SG-LS6 - ERC Starting Grant - Immunity and infection

Call for proposal

Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.

ERC-2010-StG_20091118
See other projects for this call

Funding Scheme

Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.

ERC-SG - ERC Starting Grant

Host institution

Beneficiaries (1)