Objective
The objective of this proposal is to take advantage of recently developed technological progresses in the field of live imaging to elucidate the pathogenesis of hepatitis B virus (HBV) infection.
CD8 T cells play a major part in the development of liver disease and the resolution of HBV infection. A number of important issues pertaining to HBV pathogenesis remain unresolved and they include the way in which CD8 T cells traffic and recognize antigen within the liver and the way in which the diseased liver influences these processes. Our rationale is based on the notion that - at last - we can address these and other related issues experimentally.
Single- and two-photon intravital microscopy will be carried out in un-inflamed or fibrotic/cirrhotic livers from mouse models that include transgenic mice that express all of the viral polypeptides and replicate HBV in the hepatocyte and normal mice infected with HBV-replicating, hepatotropic, fluorescent adenoviruses. The spatial and temporal constraints of naïve or effector HBV-specific CD8 T cells recognizing viral antigens and interacting intrahepatically with platelets, endothelial cells or Kupffer cells will be visualized thanks to experimental systems created specifically for this purpose.
These studies will shed new light on previously unknown aspects of HBV pathogenesis, paving the road to new immunotherapeutic strategies aimed at terminating chronic HBV infection. Results from this proposal may also have far-reaching implications, not only in related liver infections (i.e. hepatitis C virus), but also in other T cell-mediated pathological conditions of the liver such as autoimmunity, graft rejection or cancer.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2010-RG
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Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
20132 MILANO
Italy
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.