Objective
Like everything in biology, the genome is a product of evolution. In our own history, mutations that duplicate genes have generated extensive multigene families and classes, including a great diversity of transcriptional regulators involved in development of cells, tissues and organs. For example, two complete genome duplication events occurred in early vertebrate evolution (known as 2R), a third genome duplication occurred at the base of teleost fish (3R), and there were extensive tandem gene duplications in placental mammals. What role did these events play in animal evolution? How do newly duplicate genes diverge in function? Why do tandem gene duplicates evolve in a different way to whole genome duplicates? The proposed research programme aims to resolve these questions. The long-term functional consequences of duplication will be examined by examining how the spectrum of target genes differs, or overlaps, between transcription factors known to have duplicated in the 2R and 3R events. To understand the earliest stages of duplicate gene evolution gene sequences and gene expression will be studied in a spectrum of animals descendent from much more recent genome duplications, including several freshwater fish and desert-living rodents. The contrast between whole genome and tandem gene duplication will be examined in parallel, through genomic and protein-engineering studies of novel homeobox genes that arose in mammalian evolution. The programme of research is novel and will create physical and knowledge-based resources relevant to genomics, evolution, development, physiology and biomedical genetics.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences evolutionary biology
- natural sciences biological sciences freshwater biology
- natural sciences biological sciences genetics mutation
- natural sciences biological sciences zoology mammalogy
- natural sciences biological sciences genetics genomes
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
ERC-2010-AdG_20100317
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Host institution
OX1 2JD Oxford
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.