Objective
Atherosclerosis is the leading cause of morbidity and mortality in the developed world. The prevalence of this disease in the European Union (EU) has an immense social and economic impact; the problem will be further exacerbated by the aging population in this community. The current proposal aims to advance understanding of the initiation of atherosclerosis ( hence the underlying cause of clinical conditions such as heart attacks) by developing and using numerical models of the transport of water and macromolecules in the arterial wall; such transport is known to be involved in the development of the disease, but is poorly understood. The key issue is that many of the details of transport are elusive and no reliable methods of measurement are available. The study will include multiscale models of the arterial wall, where advanced mathematical models that include the different layers and cellular make up of the arterial wall will be coupled into a higher order finite element numerical method. With this model it will be possible to determine regions where macromolecules become trapped within the wall (and, by implication, where atherosclerosis will form). The proposed models will be backed up by experimental studies of macromolecule uptake in the arterial wall. The knowledge gained in the study could be used in the development of novel pharmacological interventions and hence in reducing prevalence of the disease.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- social sciences sociology demography mortality
- medical and health sciences clinical medicine cardiology cardiovascular diseases arteriosclerosis
- natural sciences mathematics applied mathematics numerical analysis
- natural sciences mathematics applied mathematics mathematical model
You need to log in or register to use this function
We are sorry... an unexpected error occurred during execution.
You need to be authenticated. Your session might have expired.
Thank you for your feedback. You will soon receive an email to confirm the submission. If you have selected to be notified about the reporting status, you will also be contacted when the reporting status will change.
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2011-CIG
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
MC-CIG - Support for training and career development of researcher (CIG)
Coordinator
SW7 2AZ London
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.