Objective
A common challenge for all organisms is to interact favourably with their environments. The blueprint to do so is in their DNA. We understand relatively well DNA units that code for proteins but cutting-edge genomic technologies have identified predominantly non-coding regions that respond to environmental cues. Thus, how widespread non-coding transcription may be functional represents a key question in modern biology.
My proposal addresses this topic by studying nascent transcription by RNA Polymerase II (Pol II) during plant environmental interaction. The novel and innovative approach promises unprecedented detail and down to single nucleotide resolution of active Pol II transcription dynamics in response to environmental cues. It will capture non-coding transcripts before they are degraded, enabling us to investigate the molecular events in largely mysterious yet abundant components of the genomic blueprints of life.
Owing to their sessile life-style, plants are experts in mediating compensatory regulation to respond to the environment. Hence, they are particularly promising models to yield answers to this contemporary scientific question. A major interest of the action will be how plants respond to low temperature. I will generate genomic maps of Pol II in the act of transcription that will reveal the dynamics of transcription in response to low temperatures. In a targeted approach, I will identify and characterise the dynamics of coding and non-coding transcription in the genomic regions responsible for cold acclimation.
My strong background and solid track record, the expertise and potential of the host supervisor together with the infrastructure and encouraging scientific atmosphere at the host department will synergistically contribute to maximise the output of the proposal. It will strengthen the competitiveness of Europe and develop and diversify my skills as an independent researcher and prepare me for a successful career within academia.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences biochemistry biomolecules nucleic acids
- natural sciences biological sciences genetics DNA
- natural sciences biological sciences biochemistry biomolecules proteins
- natural sciences biological sciences genetics RNA transcriptomes
- natural sciences biological sciences genetics nucleotides
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions
MAIN PROGRAMME
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H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
MSCA-IF-EF-ST - Standard EF
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) H2020-MSCA-IF-2015
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
1165 KOBENHAVN
Denmark
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.