Project description
Magnetic resonance advances could help reveal the metabolic signatures of diseases
Scientists working on nuclear magnetic resonance and magnetic resonance imaging are prominent examples of how interdisciplinary collaboration can benefit science and society. The fields have led to significant advances in a wide range of disciplines from chemistry to life sciences. However, the low inherent sensitivity of the methods makes their extension to the nanoscale, and therefore the observation of metabolic processes, impossible. To address this challenge, the EU-funded HyperQ project will pioneer methods to control solid-state spins at room temperature. This will increase nuclear spin polarisation several orders of magnitude above thermal equilibrium and thereby revolutionise state-of-the-art magnetic resonance. The HyperQ technology will help reveal the metabolic signatures of a broad range of diseases including cancer, Alzheimer’s and other neurodegenerative disorders.
Objective
Many of the most remarkable contributions of modern science to society have arisen from the interdisciplinary work of scientists enabling novel methods of imaging and sensing. Outstanding examples are nuclear magnetic resonance (NMR) and magnetic resonance imaging (MRI) which have enabled fundamental insights in a broad range of sciences extending from Chemistry to the Life Sciences. However, the key challenge of NMR and MRI is their very low inherent sensitivity due to the weak nuclear spin polarisation under ambient conditions. This makes the extension of magnetic resonance to the nanoscale (small volumes) and to the observation of metabolic processes (low concentrations) impossible.
HyperQ will address this challenge with the development of room-temperature quantum control of solid-state spins to increase nuclear spin polarisation several orders of magnitude above thermal equilibrium and thereby revolutionise the state-of-the-art of magnetic resonance. Essential for this development is the synergy of an interdisciplinary team of world leaders in quantum control and hyperpolarised magnetic resonance to enable the development of quantum control theory (“Quantum Software”), quantum materials (“Quantum Hardware”), their integration (“Quantum Devices”) and applications to biological and medical imaging (“Medical Quantum Applications”). HyperQ will target major breakthroughs in the field of magnetic resonance, which include chip-integrated hyperpolarisation devices designed to operate in combination with portable magnetic resonance quantum sensors, unprecedented sensitivity of bio-NMR at the nanoscale, and biomarkers of deranged cellular metabolism.
The HyperQ technology will provide access to metabolic processes from the micron to the nanoscale and thereby insights into metabolic signatures of a broad range of disease such as cancer, Alzheimer and the mechanisms behind neurodegenerative disease. This will enable fundamentally new insights into the Life Sciences.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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H2020-EU.1.1. - EXCELLENT SCIENCE - European Research Council (ERC)
MAIN PROGRAMME
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
ERC-SyG - Synergy grant
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) ERC-2019-SyG
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
89081 Ulm
Germany
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.