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O2SENSE Report Summary

Project ID: 617107
Funded under: FP7-IDEAS-ERC
Country: United Kingdom

Periodic Report Summary 2 - O2SENSE (Oxygen Sensing with Multimodality Imaging Probes)

This project addresses the current unmet clinical need for new Imaging agents to supersede those currently used for imaging hypoxic tumours (in particular prostate cancer tumours) and which are not sensitive enough to the level of oxygen in vivo (pO2) to provide the desired level of selectivity for accurate diagnosis. Through O2SENSE we already developed new molecular imaging probes with increased responsiveness to hypoxic microenvironments, efficacy in multiple cancer types, and the capability to deliver simultaneous structural and functional information on cells and soft tissue. To achieve these objectives, we performed research at the interface between chemistry and biomedical research to: (a) develop ‘smart’ all-in-one multimodal imaging probes, whose sensitivities to pO2 already show promise astuneable to respond to various levels of hypoxia as desired. Thus, ultra-sensitive probes are currently being provided which respond to reduced levels of hypoxia, as well as agents which are effective at lower pO2 and under anoxia. This aims to surpass the mainstay in cancer diagnosis and therapy and provides for increased selectivity for a wider range of tumours and we are focusing particularly on imaging and sensing for the early diagnosis of prostate tumours. The new probes are suitable for interlocked Positron Emission Tomography (PET), Single Photon Emission Tomography (SPECT), and optical imaging methodologies including superresolution imaging and multiphoton fluorescence lifetime imaging techniques.
This approach will provide an in depth understanding of biological processes underlining tumour hypoxia and lead to the rational design of new diagnostics and therapeutics for personalised medicine.

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United Kingdom
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