Objectif The interaction of specific biomolecules like endotoxins or certain proteins with organisms can be a major cause of diseases. Prominent examples are pyrogenes - lipopolysacharides (LPS) and lipoteichoic acids (LTA) -, which cause fever in human body and ar e potentially lethal after injection. In some cases the secondary or tertiary structure of proteins is responsible for their biological properties. Important example is PrP (prion). Some contaminated object such as a surface (e.g. medical devices, accessor ies, work surface or tissue) cannot be decontaminated with current sterilisation practices at all or only with inducing major damage to the substrate or tissue itself. An applicable innovative technology for the inactivation of pathogenic biomolecules is, therefore, urgently desired. It is proposed to exploit the feasibility of plasma discharges as decontamination device for pathogenic biomolecules. Emerging species from the plasma discharge interact individually as well as simultaneously with the biomolecu les. It is expected that this reactive particle flux is able to induce alteration and inactivation of biomolecules. This is addressed in a combined approach using low and high pressure plasma discharges. Different characteristic biomolecules are exposed to the plasmas and the changes induced are monitored. In a second step, the inactivation of resistant bacterial endospores is explored. The potential applications are in the field of surface decontamination of medical objects and surfaces as well as control of a biological environment. The results of the research will have also an important impact in the field of security and protection of citizens in front of bioterrorism. For instance, atmospheric plasma sources will be developed and validated to serve as a decontamination device in the field. The processes will also be developed to be applicable on large areas for medical applications Champ scientifique social sciencespolitical sciencespolitical transitionsterrorismnatural sciencesbiological sciencesbiochemistrybiomoleculesproteins Mots‑clés physics plasma plasma physics Programme(s) FP6-POLICIES - Policy support: Specific activities covering wider field of research under the Focusing and Integrating Community Research programme 2002-2006. Thème(s) NEST-2003-1 - Adventure activities Appel à propositions FP6-2003-NEST-B-1 Voir d’autres projets de cet appel Régime de financement STREP - Specific Targeted Research Project Coordinateur RUHR-UNIVERSITAET BOCHUM Contribution de l’UE Aucune donnée Adresse Universitaetsstrasse 150 BOCHUM Allemagne Voir sur la carte Liens Site web Opens in new window Coût total Aucune donnée Participants (4) Trier par ordre alphabétique Trier par contribution de l’UE Tout développer Tout réduire ACXYS TECHNOLOGIES France Contribution de l’UE Aucune donnée Adresse 148 rue des vingt toises SAINT MARTIN LE VINOUX Voir sur la carte Liens Site web Opens in new window Coût total Aucune donnée COMMISSARIAT A L'ENERGIE ATOMIQUE France Contribution de l’UE Aucune donnée Adresse 31-33 Rue de la Féderation PARIS Voir sur la carte Liens Site web Opens in new window Coût total Aucune donnée COMMISSION OF THE EUROPEAN COMMUNITIES - DIRECTORATE GENERAL JOINT RESEARCH CENTRE Belgique Contribution de l’UE Aucune donnée Adresse Rue de la Loi, 200 BRUSSELS Voir sur la carte Liens Site web Opens in new window Coût total Aucune donnée FRAUNHOFER GESELLSCHAFT ZUR FOERDERUNG DER ANGEWANDTEN FORSCHUNG E.V. Allemagne Contribution de l’UE Aucune donnée Adresse Hansastrasse 27 C MUENCHEN Voir sur la carte Liens Site web Opens in new window Coût total Aucune donnée
