Obiettivo The interaction of specific biomolecules like endotoxins or certain proteins with organisms can be a major cause of diseases. Prominent examples are pyrogenes - lipopolysacharides (LPS) and lipoteichoic acids (LTA) -, which cause fever in human body and ar e potentially lethal after injection. In some cases the secondary or tertiary structure of proteins is responsible for their biological properties. Important example is PrP (prion). Some contaminated object such as a surface (e.g. medical devices, accessor ies, work surface or tissue) cannot be decontaminated with current sterilisation practices at all or only with inducing major damage to the substrate or tissue itself. An applicable innovative technology for the inactivation of pathogenic biomolecules is, therefore, urgently desired. It is proposed to exploit the feasibility of plasma discharges as decontamination device for pathogenic biomolecules. Emerging species from the plasma discharge interact individually as well as simultaneously with the biomolecu les. It is expected that this reactive particle flux is able to induce alteration and inactivation of biomolecules. This is addressed in a combined approach using low and high pressure plasma discharges. Different characteristic biomolecules are exposed to the plasmas and the changes induced are monitored. In a second step, the inactivation of resistant bacterial endospores is explored. The potential applications are in the field of surface decontamination of medical objects and surfaces as well as control of a biological environment. The results of the research will have also an important impact in the field of security and protection of citizens in front of bioterrorism. For instance, atmospheric plasma sources will be developed and validated to serve as a decontamination device in the field. The processes will also be developed to be applicable on large areas for medical applications Campo scientifico social sciencespolitical sciencespolitical transitionsterrorismnatural sciencesbiological sciencesbiochemistrybiomoleculesproteins Parole chiave physics plasma plasma physics Programma(i) FP6-POLICIES - Policy support: Specific activities covering wider field of research under the Focusing and Integrating Community Research programme 2002-2006. Argomento(i) NEST-2003-1 - Adventure activities Invito a presentare proposte FP6-2003-NEST-B-1 Vedi altri progetti per questo bando Meccanismo di finanziamento STREP - Specific Targeted Research Project Coordinatore RUHR-UNIVERSITAET BOCHUM Contributo UE Nessun dato Indirizzo Universitaetsstrasse 150 BOCHUM Germania Mostra sulla mappa Collegamenti Sito web Opens in new window Costo totale Nessun dato Partecipanti (4) Classifica in ordine alfabetico Classifica per Contributo UE Espandi tutto Riduci tutto ACXYS TECHNOLOGIES Francia Contributo UE Nessun dato Indirizzo 148 rue des vingt toises SAINT MARTIN LE VINOUX Mostra sulla mappa Collegamenti Sito web Opens in new window Costo totale Nessun dato COMMISSARIAT A L'ENERGIE ATOMIQUE Francia Contributo UE Nessun dato Indirizzo 31-33 Rue de la Féderation PARIS Mostra sulla mappa Collegamenti Sito web Opens in new window Costo totale Nessun dato COMMISSION OF THE EUROPEAN COMMUNITIES - DIRECTORATE GENERAL JOINT RESEARCH CENTRE Belgio Contributo UE Nessun dato Indirizzo Rue de la Loi, 200 BRUSSELS Mostra sulla mappa Collegamenti Sito web Opens in new window Costo totale Nessun dato FRAUNHOFER GESELLSCHAFT ZUR FOERDERUNG DER ANGEWANDTEN FORSCHUNG E.V. Germania Contributo UE Nessun dato Indirizzo Hansastrasse 27 C MUENCHEN Mostra sulla mappa Collegamenti Sito web Opens in new window Costo totale Nessun dato