Obiettivo Cardiac arrhythmia is a major cause of morbidity and mortality in Europe and of growing socio-economic concern. Recent data suggest that novel mechanisms such as HCN channels, mechanical effects on Ca handling and ion flux balances, and cellular heterogeneity may trigger and/or permit the sustenance of arrhythmias. The novelty of our approach is to focus on these potentially crucial, but ill-investigated, mechanisms by uniting 8 leading labs from 5EU countries who focus on individual arrhythmogenic aspects, in a bid to combine their expertise and shed light on how physiological or compensatory mechanisms may turn arrhythmogenic, and how this may be controlled or corrected.Prime targets are structured along three levels of functional integration:-Membrane level: Role of HCN channels in the generation of normal and abnormal rhythm-Cellular level: Role of electro-mechanical interaction in modulating contractile activity and electrophysiology-Multicellular level: Role of heterogeneity in normal and remodelled tissue on electrical excitation and conductionScientific and technological objectives:-To develop suitable experimental tools, including HCN transgenic mice, novel bradycardic and antiarrhythmic agents, control of mechano-electrical interactions, and the symbiosis of the above-To acquire new knowledge on molecular mechanisms and pathways controlling generation and spread of excitation in normal and diseased cardiac tissue-To combine advanced engineering techniques for 'top-down' development of novel experimental tools with mathematical 'bottom-up' integration of data from the molecular level to fundamental and clinical relevanceBased on the combination of skills and techniques not currently available in any single lab worldwide, we will provide novel insight into novel arrhythmogenic mechanisms, quantify their interrelation, target preventive and therapeutic interventions to reduce the societal and economical impact of cardiac arrhythmia Campo scientifico medical and health sciencesclinical medicinecardiologycardiovascular diseasescardiac arrhythmiasocial sciencessociologydemographymortalitynatural scienceschemical sciencesinorganic chemistryalkali metalsmedical and health sciencesbasic medicinephysiologynatural sciencesmathematicsapplied mathematicsmathematical model Programma(i) FP6-LIFESCIHEALTH - Life sciences, genomics and biotechnology for health: Thematic Priority 1 under the Focusing and Integrating Community Research programme 2002-2006. Argomento(i) LSH-2004-2.1.1-4 - Arrhythmia and ion channels Invito a presentare proposte FP6-2004-LIFESCIHEALTH-5 Vedi altri progetti per questo bando Meccanismo di finanziamento STREP - Specific Targeted Research Project Coordinatore UNIVERSITA DEGLI STUDI DI FIRENZE Contributo UE Nessun dato Indirizzo Piazza S Marco 4 FIRENZE Italia Mostra sulla mappa Collegamenti Sito web Opens in new window Costo totale Nessun dato Partecipanti (7) Classifica in ordine alfabetico Classifica per Contributo UE Espandi tutto Riduci tutto LUDWIG-MAXIMILIANS-UNIVERSITÄT MÜNCHEN Germania Contributo UE Nessun dato Indirizzo Geschwister-Scholl-Platz 1 MÜNCHEN Mostra sulla mappa Collegamenti Sito web Opens in new window Costo totale Nessun dato TECHNISCHE UNIVERSITÄT DRESDEN Germania Contributo UE Nessun dato Indirizzo Helmholtzstr. 10 DRESDEN Mostra sulla mappa Collegamenti Sito web Opens in new window Costo totale Nessun dato THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD Regno Unito Contributo UE Nessun dato Indirizzo University Offices, Wellington Square OXFORD Mostra sulla mappa Collegamenti Sito web Opens in new window Costo totale Nessun dato THE UNIVERSITY OF MANCHESTER Regno Unito Contributo UE Nessun dato Indirizzo Street Oxford Road MANCHESTER Mostra sulla mappa Collegamenti Sito web Opens in new window Costo totale Nessun dato UNIVERSITA DEGLI STUDI DI MILANO Italia Contributo UE Nessun dato Indirizzo Via Festa del Perdono 7 MILANO Mostra sulla mappa Collegamenti Sito web Opens in new window Costo totale Nessun dato UNIVERSITEIT MAASTRICHT Paesi Bassi Contributo UE Nessun dato Indirizzo Universiteitssingel 50 MAASTRICHT Mostra sulla mappa Collegamenti Sito web Opens in new window Costo totale Nessun dato UNIVERSITY OF SZEGED Ungheria Contributo UE Nessun dato Indirizzo Dugonics tEr 13 SZEGED Mostra sulla mappa Collegamenti Sito web Opens in new window Costo totale Nessun dato