Cel
Stroke poses a massive clinical, social and economic burden, yet we have very limited effective therapies. This inadequacy is in spite of intensive research efforts and numerous failed clinical trials. Leading European stroke researchers and clinicians with a track record of established cooperation will share their complementary expertise, and team up with SME partners with high profile R&D and ongoing, promising clinical trials. Based on a thorough reexamination of the failures and bottlenecks of previous attempts to develop effective therapies for stroke, the ARISE consortium proposes an integrative and innovative approach to overcome the translational roadblock. ARISE research will result in a number of novel, promising therapies, including safer thrombolytics, modulators of the immune system and inflammation, compounds inducing or mimicking endogenous neuroprotection, therapies to induce repair of lost function, as well as a fast way to selectively cool the brain. We will work on a common model and methods platform, in which for the first time relevant comorbidities, gender, age, and long term outcomes will be investigated. Training of young researchers will lead to a standardisation and harmonisation of laboratory practices within the consortium, and implement the standard operating procedures generated by the consortium. Importantly, the ARISE consortium combines expertise in clinical as well as preclinical stroke research. To obtain clinical proof of principle and to translate our findings into effective therapy of stroke, ARISE is conducting clinical trials and has established a dedicated clinical platform to (1) provide advice to the basic researchers of the consortium with regard to clinically relevant questions and modelling, (2) to periodically review the ongoing development of innovative therapies, and to (3) ultimately take the most promising preclinical strategy developed by the ARISE consortium into a multicenter randomized clinical trial.
Dziedzina nauki
Słowa kluczowe
Zaproszenie do składania wniosków
FP7-HEALTH-2007-A
Zobacz inne projekty w ramach tego zaproszenia
System finansowania
CP-IP - Large-scale integrating projectKoordynator
10117 Berlin
Niemcy
Zobacz na mapie
Uczestnicy (16)
70211 KUOPIO
Zobacz na mapie
22100 LUND
Zobacz na mapie
69117 Heidelberg
Zobacz na mapie
08036 Barcelona
Zobacz na mapie
M13 9PL Manchester
Zobacz na mapie
75654 Paris
Zobacz na mapie
8006 ZURICH
Zobacz na mapie
02 093 Warszawa
Zobacz na mapie
9000 Gent
Zobacz na mapie
22370 LUND
Zobacz na mapie
52062 AACHEN
Zobacz na mapie
Zakończenie uczestnictwa
69120 HEIDELBERG
Zobacz na mapie
2750 BALLERUP
Zobacz na mapie
80333 Muenchen
Zobacz na mapie
69120 Heidelberg
Zobacz na mapie
23562 Lubeck
Zobacz na mapie