Objective
Stroke poses a massive clinical, social and economic burden, yet we have very limited effective therapies. This inadequacy is in spite of intensive research efforts and numerous failed clinical trials. Leading European stroke researchers and clinicians with a track record of established cooperation will share their complementary expertise, and team up with SME partners with high profile R&D and ongoing, promising clinical trials. Based on a thorough reexamination of the failures and bottlenecks of previous attempts to develop effective therapies for stroke, the ARISE consortium proposes an integrative and innovative approach to overcome the translational roadblock. ARISE research will result in a number of novel, promising therapies, including safer thrombolytics, modulators of the immune system and inflammation, compounds inducing or mimicking endogenous neuroprotection, therapies to induce repair of lost function, as well as a fast way to selectively cool the brain. We will work on a common model and methods platform, in which for the first time relevant comorbidities, gender, age, and long term outcomes will be investigated. Training of young researchers will lead to a standardisation and harmonisation of laboratory practices within the consortium, and implement the standard operating procedures generated by the consortium. Importantly, the ARISE consortium combines expertise in clinical as well as preclinical stroke research. To obtain clinical proof of principle and to translate our findings into effective therapy of stroke, ARISE is conducting clinical trials and has established a dedicated clinical platform to (1) provide advice to the basic researchers of the consortium with regard to clinically relevant questions and modelling, (2) to periodically review the ongoing development of innovative therapies, and to (3) ultimately take the most promising preclinical strategy developed by the ARISE consortium into a multicenter randomized clinical trial.
Fields of science
Keywords
Call for proposal
FP7-HEALTH-2007-A
See other projects for this call
Funding Scheme
CP-IP - Large-scale integrating projectCoordinator
10117 Berlin
Germany
See on map
Participants (16)
70211 KUOPIO
See on map
22100 LUND
See on map
69117 Heidelberg
See on map
08036 Barcelona
See on map
M13 9PL Manchester
See on map
75654 Paris
See on map
8006 ZURICH
See on map
02 093 Warszawa
See on map
9000 Gent
See on map
22370 LUND
See on map
52062 AACHEN
See on map
Participation ended
69120 HEIDELBERG
See on map
2750 BALLERUP
See on map
80333 Muenchen
See on map
69120 Heidelberg
See on map
23562 Lubeck
See on map