Objectif Influenza is an extremely contagious infection that is caused by distinct virus types and subtypes. Early diagnosis is crucial for disease treatment and control as it reduces the inappropriate use of antibiotics and provides the indication for antiviral therapy. Rapid diagnosis is also a key component of surveillance activity. This requires the ability to detect and accurately diagnose infection at or close to the source/outbreak with minimum delay, a tactic consistent with the global experience during the SARS epidemic in 2003. This experience underlines the need for specific, sensitive point-of-care testing capable of discriminating between influenza subtypes. None of the available influenza diagnostic assays combines a point-of-care format with the multiplex capability to identify a large repertoire of human and animal viruses. This project exploits the knowledge and the expertise of the partners to convert microarray assays, that have a powerful multiplex capability but are laborious, complex and expensive to perform, into a simple, robust and affordable automated point-of-care system for the diagnosis of influenza. The system will utilize three components: 1) a microarray immunoassay that distinguishes influenza A and B virus as well as A subtypes; 2) an innovative self-contained disposable lateral-flow device that allows the addition of specimens and reagents in a temporally-controlled manner; 3) a robust automated processing reading instrument of novel conception that employs a low cost, high performance optical module. This project will provide small laboratories, health offices, veterinary clinics and outposts (airports) with the diagnostic capability of major research institutions and reference centres, thus providing better care for patients and most importantly, facilitating the implementation of surveillance activities and guiding response measures that are being built to face a possible influenza pandemic caused by a highly virulent virus. Champ scientifique medical and health scienceshealth sciencesinfectious diseasesRNA virusesinfluenzamedical and health scienceshealth sciencesinfectious diseasesRNA virusescoronaviruses Mots‑clés Bioinformatics Genomics Influenza Micro-array Point-of-care Proteomics Serodiagnosis Programme(s) FP7-HEALTH - Specific Programme "Cooperation": Health Thème(s) HEALTH-2007-2.3.3-4 - Innovative point-of-care diagnostic tests for influenza Appel à propositions FP7-HEALTH-2007-A Voir d’autres projets de cet appel Régime de financement CP-TP - Collaborative Project targeted to a special group (such as SMEs) Coordinateur UNIVERSITA DEGLI STUDI DI PERUGIA Contribution de l’UE € 946 798,30 Adresse PIAZZA DELL UNIVERSITA 1 06123 Perugia Italie Voir sur la carte Région Centro (IT) Umbria Perugia Type d’activité Higher or Secondary Education Establishments Contact administratif Ennio Becchetti (Prof.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée Participants (5) Trier par ordre alphabétique Trier par contribution de l’UE Tout développer Tout réduire HEALTH PROTECTION AGENCY HPA Participation terminée Royaume-Uni Contribution de l’UE € 215 993,17 Adresse BUCKINGHAM PALACE ROAD 151 SW1W 9SZ London Voir sur la carte Type d’activité Research Organisations Contact administratif David Conway (Mr.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée ISTITUTO SUPERIORE DI SANITA Italie Contribution de l’UE € 308 200,00 Adresse Viale Regina Elena 299 00161 Roma Voir sur la carte Région Centro (IT) Lazio Roma Type d’activité Research Organisations Contact administratif Rosa Maria Martoccia (Dr.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée PX'Therapeutics France Contribution de l’UE € 193 125,00 Adresse 15, rue des Martyrs 38027 GRENOBLE Voir sur la carte Type d’activité Private for-profit entities (excluding Higher or Secondary Education Establishments) Contact administratif Tristan Rousselle (Dr.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée MICROTEST MATRICES LTD Royaume-Uni Contribution de l’UE € 822 676,53 Adresse EXHIBITION ROAD, BESSEMER BUILDING SW7 2AZ LONDON Voir sur la carte Région London Inner London — West Westminster Type d’activité Private for-profit entities (excluding Higher or Secondary Education Establishments) Contact administratif Clelia Supparo (Ms.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée SEAC Italie Contribution de l’UE € 289 200,00 Adresse Via de Prato 74 50041 CALENZANO- FIRENZE Voir sur la carte Type d’activité Private for-profit entities (excluding Higher or Secondary Education Establishments) Contact administratif Angelo Manzoni (Dr.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée