Objetivo Influenza is an extremely contagious infection that is caused by distinct virus types and subtypes. Early diagnosis is crucial for disease treatment and control as it reduces the inappropriate use of antibiotics and provides the indication for antiviral therapy. Rapid diagnosis is also a key component of surveillance activity. This requires the ability to detect and accurately diagnose infection at or close to the source/outbreak with minimum delay, a tactic consistent with the global experience during the SARS epidemic in 2003. This experience underlines the need for specific, sensitive point-of-care testing capable of discriminating between influenza subtypes. None of the available influenza diagnostic assays combines a point-of-care format with the multiplex capability to identify a large repertoire of human and animal viruses. This project exploits the knowledge and the expertise of the partners to convert microarray assays, that have a powerful multiplex capability but are laborious, complex and expensive to perform, into a simple, robust and affordable automated point-of-care system for the diagnosis of influenza. The system will utilize three components: 1) a microarray immunoassay that distinguishes influenza A and B virus as well as A subtypes; 2) an innovative self-contained disposable lateral-flow device that allows the addition of specimens and reagents in a temporally-controlled manner; 3) a robust automated processing reading instrument of novel conception that employs a low cost, high performance optical module. This project will provide small laboratories, health offices, veterinary clinics and outposts (airports) with the diagnostic capability of major research institutions and reference centres, thus providing better care for patients and most importantly, facilitating the implementation of surveillance activities and guiding response measures that are being built to face a possible influenza pandemic caused by a highly virulent virus. Ámbito científico medical and health scienceshealth sciencesinfectious diseasesRNA virusesinfluenzamedical and health scienceshealth sciencesinfectious diseasesRNA virusescoronaviruses Palabras clave Bioinformatics Genomics Influenza Micro-array Point-of-care Proteomics Serodiagnosis Programa(s) FP7-HEALTH - Specific Programme "Cooperation": Health Tema(s) HEALTH-2007-2.3.3-4 - Innovative point-of-care diagnostic tests for influenza Convocatoria de propuestas FP7-HEALTH-2007-A Consulte otros proyectos de esta convocatoria Régimen de financiación CP-TP - Collaborative Project targeted to a special group (such as SMEs) Coordinador UNIVERSITA DEGLI STUDI DI PERUGIA Aportación de la UE € 946 798,30 Dirección PIAZZA DELL UNIVERSITA 1 06123 Perugia Italia Ver en el mapa Región Centro (IT) Umbria Perugia Tipo de actividad Higher or Secondary Education Establishments Contacto administrativo Ennio Becchetti (Prof.) Enlaces Contactar con la organización Opens in new window Sitio web Opens in new window Coste total Sin datos Participantes (5) Ordenar alfabéticamente Ordenar por aportación de la UE Ampliar todo Contraer todo HEALTH PROTECTION AGENCY HPA La participación finalizó Reino Unido Aportación de la UE € 215 993,17 Dirección BUCKINGHAM PALACE ROAD 151 SW1W 9SZ London Ver en el mapa Tipo de actividad Research Organisations Contacto administrativo David Conway (Mr.) Enlaces Contactar con la organización Opens in new window Sitio web Opens in new window Coste total Sin datos ISTITUTO SUPERIORE DI SANITA Italia Aportación de la UE € 308 200,00 Dirección Viale Regina Elena 299 00161 Roma Ver en el mapa Región Centro (IT) Lazio Roma Tipo de actividad Research Organisations Contacto administrativo Rosa Maria Martoccia (Dr.) Enlaces Contactar con la organización Opens in new window Sitio web Opens in new window Coste total Sin datos PX'Therapeutics Francia Aportación de la UE € 193 125,00 Dirección 15, rue des Martyrs 38027 GRENOBLE Ver en el mapa Tipo de actividad Private for-profit entities (excluding Higher or Secondary Education Establishments) Contacto administrativo Tristan Rousselle (Dr.) Enlaces Contactar con la organización Opens in new window Sitio web Opens in new window Coste total Sin datos MICROTEST MATRICES LTD Reino Unido Aportación de la UE € 822 676,53 Dirección EXHIBITION ROAD, BESSEMER BUILDING SW7 2AZ LONDON Ver en el mapa Región London Inner London — West Westminster Tipo de actividad Private for-profit entities (excluding Higher or Secondary Education Establishments) Contacto administrativo Clelia Supparo (Ms.) Enlaces Contactar con la organización Opens in new window Sitio web Opens in new window Coste total Sin datos SEAC Italia Aportación de la UE € 289 200,00 Dirección Via de Prato 74 50041 CALENZANO- FIRENZE Ver en el mapa Tipo de actividad Private for-profit entities (excluding Higher or Secondary Education Establishments) Contacto administrativo Angelo Manzoni (Dr.) Enlaces Contactar con la organización Opens in new window Sitio web Opens in new window Coste total Sin datos