Multifunctional DNA light-switches: sensors and devices

Projektinformationen

LIGHTSWITCHES

ID Finanzhilfevereinbarung: 219291

Abgeschlossenes Projekt

Startdatum 20 April 2009

Enddatum 19 April 2011

Finanziert unter

• Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)

Gesamtkosten € 169 957,94

EU-Beitrag € 169 957,94

Koordiniert durch

THE UNIVERSITY OF SHEFFIELD
United Kingdom

Ziel

Photoactive mono- and oligonuclear transition metal complexes containing DNA intercalative ligands will be synthesized. In the latter case, both homo- and heterometallic complexes will be synthesized. The photophysical properties of the complexes will be exploited to produce a number of outcomes: prototypical sensors for DNA sequences and/or structures that will produce a luminescent output on DNA binding, tools for investigating DNA/substrate binding events and the photophysical/electronic properties of DNA. The synthesis of multi-functional probes will also be investigated; e.g. DNA light-switches that also cleave DNA (directly OR through singlet oxygen sensitizing) and/or display cytotoxicity. To fully understand the properties of the new systems and their interaction with DNA studies will encompass a wide spectrum of techniques from time resolved optical spectroscopy, to calorimetry and in cellulo studies.

Wissenschaftliches Gebiet

• natural sciences › biological sciences › genetics › DNA
• natural sciences › chemical sciences › analytical chemistry › calorimetry
• engineering and technology › electrical engineering, electronic engineering, information engineering › electronic engineering › sensors
• natural sciences › physical sciences › optics › spectroscopy

Schlüsselbegriffe

• Chemistry
• Molecular chemistry
• Molecular markers and recognition
• Nanodevices
• Physical sciences

Programm/Programme

• FP7-PEOPLE - Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)

Thema/Themen

• PEOPLE-2007-4-2.IIF - Marie Curie Action: "International Incoming Fellowships"

Aufforderung zur Vorschlagseinreichung

FP7-PEOPLE-2007-4-2-IIF
Andere Projekte für diesen Aufruf anzeigen

Finanzierungsplan

MC-IIF - International Incoming Fellowships (IIF)

Koordinator

THE UNIVERSITY OF SHEFFIELD

Kontakt Verwaltung

Gill Wells (Ms.)

• EU-Beitrag: € 169 957,94
• Adresse: FIRTH COURT WESTERN BANK ; S10 2TN Sheffield ; Vereinigtes Königreich
• Region: Yorkshire and the Humber › South Yorkshire › Sheffield
• Aktivitätstyp: Higher or Secondary Education Establishments
• Gesamtkosten: Keine Daten