Objectif Photoactive mono- and oligonuclear transition metal complexes containing DNA intercalative ligands will be synthesized. In the latter case, both homo- and heterometallic complexes will be synthesized. The photophysical properties of the complexes will be exploited to produce a number of outcomes: prototypical sensors for DNA sequences and/or structures that will produce a luminescent output on DNA binding, tools for investigating DNA/substrate binding events and the photophysical/electronic properties of DNA. The synthesis of multi-functional probes will also be investigated; e.g. DNA light-switches that also cleave DNA (directly OR through singlet oxygen sensitizing) and/or display cytotoxicity. To fully understand the properties of the new systems and their interaction with DNA studies will encompass a wide spectrum of techniques from time resolved optical spectroscopy, to calorimetry and in cellulo studies. Champ scientifique natural sciencesbiological sciencesgeneticsDNAnatural scienceschemical sciencesanalytical chemistrycalorimetryengineering and technologyelectrical engineering, electronic engineering, information engineeringelectronic engineeringsensorsnatural sciencesphysical sciencesopticsspectroscopy Mots‑clés Chemistry Molecular chemistry Molecular markers and recognition Nanodevices Physical sciences Programme(s) FP7-PEOPLE - Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Thème(s) PEOPLE-2007-4-2.IIF - Marie Curie Action: "International Incoming Fellowships" Appel à propositions FP7-PEOPLE-2007-4-2-IIF Voir d’autres projets de cet appel Régime de financement MC-IIF - International Incoming Fellowships (IIF) Coordinateur THE UNIVERSITY OF SHEFFIELD Contribution de l’UE € 169 957,94 Adresse FIRTH COURT WESTERN BANK S10 2TN Sheffield Royaume-Uni Voir sur la carte Région Yorkshire and the Humber South Yorkshire Sheffield Type d’activité Higher or Secondary Education Establishments Contact administratif Gill Wells (Ms.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée
