Obiettivo Metastasis is the process whereby a primary tumor (usually highly malignant in nature) spreads to distant locations in the body. Understanding step-by-step how particular confined tumors acquire invasiveness and/or spreading potential is a scientific challenge that can help us to develop new strategies for metastatic cancer prevention or treatment. In mouse models and in humans, the inactivation of the E-cadherin gene and the activation of genes of the SNAIL family are markers of the initiation of metastasis from epithelial tumors – a process that is called epithelial-mesenchimal transition, and that is similar, albeit not identical, to what occurs during normal development. In vivo, however, neither the activation of E-cadherin nor the activation of SNAIL genes is sufficient to trigger malignant transformation, indicating that additional unknown factors are required for this process to take place. Our project has as its main objective to develop and explore genetically traceable animal models that recapitulate the initial steps in malignant transformation of tumorous growth in vivo. With these animal models we intend to understand the molecular mechanisms that activate (or inactivate) genes that trigger metastasis and that convert a stationary eptithelial cell into an invasive one (ie, one with the capacity to invade and degrade the basal lamina). We hope that these models will help to open new fields of investigation to isolate new potential targets for therapeutic intervention. Campo scientifico medical and health sciencesclinical medicineoncology Parole chiave Animal growth Cell Invasion Cell biology Genetics Metastasis Model organism Natural sciences Tumour Programma(i) FP7-PEOPLE - Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Argomento(i) PEOPLE-2007-2-1.IEF - Marie Curie Action: "Intra-European Fellowships for Career Development" Invito a presentare proposte FP7-PEOPLE-2007-2-1-IEF Vedi altri progetti per questo bando Meccanismo di finanziamento MC-IEF - Intra-European Fellowships (IEF) Coordinatore UNIVERSIDAD MIGUEL HERNANDEZ DE ELCHE Contributo UE € 159 166,60 Indirizzo AVENIDA DE LA UNIVERSIDAD S-N 03202 Elche Spagna Mostra sulla mappa Regione Este Comunitat Valenciana Alicante/Alacant Tipo di attività Higher or Secondary Education Establishments Contatto amministrativo Rafael Gandía Balaguer (Mr.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato
