Obiettivo The organisation of the genome into separate domains and sub-compartments through higher order chromatin structure is an important means by which eukaryotic cells control nuclear processes such as DNA transcription and repair. Recent evidence has implicated sumoylation as an important regulator of global nuclear architecture as well as allied processes such as telomere maintenance and DNA damage repair. Using the yeast Saccharomyces cerevisiae as a model organism to look at nuclear dynamics in vivo, we aim to elucidate the mechanism by which SUMO modification regulates these processes. Campo scientifico natural sciencesbiological sciencesgeneticsDNAnatural sciencesbiological sciencesgeneticsgenomes Parole chiave DNA damage Genome stability Nuclear organisation SUMO modification Snf2 proteins Telomere maintenance Programma(i) FP7-PEOPLE - Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Argomento(i) PEOPLE-2007-2-1.IEF - Marie Curie Action: "Intra-European Fellowships for Career Development" Invito a presentare proposte FP7-PEOPLE-2007-2-1-IEF Vedi altri progetti per questo bando Meccanismo di finanziamento MC-IEF - Intra-European Fellowships (IEF) Coordinatore Novartis Forschungsstiftung Contributo UE € 179 297,73 Indirizzo Maulbeerstrasse 66 4058 BASEL Svizzera Mostra sulla mappa Tipo di attività Research Organisations Contatto amministrativo Susan Gasser (Prof.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato
