Objetivo The organisation of the genome into separate domains and sub-compartments through higher order chromatin structure is an important means by which eukaryotic cells control nuclear processes such as DNA transcription and repair. Recent evidence has implicated sumoylation as an important regulator of global nuclear architecture as well as allied processes such as telomere maintenance and DNA damage repair. Using the yeast Saccharomyces cerevisiae as a model organism to look at nuclear dynamics in vivo, we aim to elucidate the mechanism by which SUMO modification regulates these processes. Ámbito científico natural sciencesbiological sciencesgeneticsDNAnatural sciencesbiological sciencesgeneticsgenomes Palabras clave DNA damage Genome stability Nuclear organisation SUMO modification Snf2 proteins Telomere maintenance Programa(s) FP7-PEOPLE - Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Tema(s) PEOPLE-2007-2-1.IEF - Marie Curie Action: "Intra-European Fellowships for Career Development" Convocatoria de propuestas FP7-PEOPLE-2007-2-1-IEF Consulte otros proyectos de esta convocatoria Régimen de financiación MC-IEF - Intra-European Fellowships (IEF) Coordinador Novartis Forschungsstiftung Aportación de la UE € 179 297,73 Dirección Maulbeerstrasse 66 4058 BASEL Suiza Ver en el mapa Tipo de actividad Research Organisations Contacto administrativo Susan Gasser (Prof.) Enlaces Contactar con la organización Opens in new window Sitio web Opens in new window Coste total Sin datos
