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Marine Metagenomics for New Biotechnological Applications

Ziel

The Project aims at the mining of individual enzymes and metabolic pathways from extremophilic marine organisms and the metagenomes from microbial communities from peculiar marine environments and consequent funnelling the new enzymatic reactions and processes towards the new biotechnological applications. Project builds up on the scientific and technological excellence of individual academic and industrial partners, and beyond that, on application of the state-of-the-art technologies for archiving, molecular screening for the activities (using a unique Surface Plasmon Resonance screening platform), protein structure elucidation, enzyme engineering and directed evolution and establishing new biotechnological processes (biocatalysis, synthesis of fine chemicals, etc.). Marine sampling hotspots to produce the metagenomic resources for their further exploration will cover the whole diversity of marine microbial life at its limits (hypersaline, low and high temperature, high pressure and low water activity conditions, etc.). Individual enzymes interacting with the substrates will be identified, and in case they are new, hyperexpressed and crystallized and their structures will be elucidated. Consequently, the most promising candidates will be scored against the chiral substrates of relevance for biocatalysis and their ability to perform in water-free systems will be evaluated, the directed evolution will be implemented to improve the performance, and specificity of the enzymes. A comprehensive bioinformatic survey throughout the whole tree of cellular life will reveal and suggest the new candidates homologous to the discovered new proteins, from other organisms to be cloned and assayed. The implementation of the set of new enzymes in the biotechnological processes for fine chemical synthesis and drug discovery will be conducted in a strong alliance with competent industrial partners.

Wissenschaftliches Gebiet

Schlüsselbegriffe

Programm/Programme

Thema/Themen

Aufforderung zur Vorschlagseinreichung

FP7-KBBE-2008-2B
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Finanzierungsplan

CP-FP - Small or medium-scale focused research project

Koordinator

BANGOR UNIVERSITY
EU-Beitrag
€ 621 144,00
Adresse
COLLEGE ROAD
LL57 2DG Bangor
Vereinigtes Königreich

Auf der Karte ansehen
Region
Wales West Wales and The Valleys Gwynedd
Aktivitätstyp
Higher or Secondary Education Establishments
Kontakt Verwaltung
Dyfan Griffith (Mr.)
Links
Gesamtkosten
Keine Daten

Beteiligte (10)

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Letzte Aktualisierung: 5 April 2023

Mein Booklet

Permalink: https://cordis.europa.eu/project/id/226977/de

European Union, 2024