Objective The Project aims at the mining of individual enzymes and metabolic pathways from extremophilic marine organisms and the metagenomes from microbial communities from peculiar marine environments and consequent funnelling the new enzymatic reactions and processes towards the new biotechnological applications. Project builds up on the scientific and technological excellence of individual academic and industrial partners, and beyond that, on application of the state-of-the-art technologies for archiving, molecular screening for the activities (using a unique Surface Plasmon Resonance screening platform), protein structure elucidation, enzyme engineering and directed evolution and establishing new biotechnological processes (biocatalysis, synthesis of fine chemicals, etc.). Marine sampling hotspots to produce the metagenomic resources for their further exploration will cover the whole diversity of marine microbial life at its limits (hypersaline, low and high temperature, high pressure and low water activity conditions, etc.). Individual enzymes interacting with the substrates will be identified, and in case they are new, hyperexpressed and crystallized and their structures will be elucidated. Consequently, the most promising candidates will be scored against the chiral substrates of relevance for biocatalysis and their ability to perform in water-free systems will be evaluated, the directed evolution will be implemented to improve the performance, and specificity of the enzymes. A comprehensive bioinformatic survey throughout the whole tree of cellular life will reveal and suggest the new candidates homologous to the discovered new proteins, from other organisms to be cloned and assayed. The implementation of the set of new enzymes in the biotechnological processes for fine chemical synthesis and drug discovery will be conducted in a strong alliance with competent industrial partners. Fields of science medical and health sciencesbasic medicinepharmacology and pharmacydrug discoverynatural scienceschemical sciencescatalysisbiocatalysisnatural sciencesbiological sciencesbiochemistrybiomoleculesproteinsenzymes Keywords biocatalysis drug discovery marine biotechnology metagenomics Programme(s) FP7-KBBE - Specific Programme "Cooperation": Food, Agriculture and Biotechnology Topic(s) KBBE-2008-3-2-07 - Industrially relevant products and processes from marine biotechnology Call for proposal FP7-KBBE-2008-2B See other projects for this call Funding Scheme CP-FP - Small or medium-scale focused research project Coordinator BANGOR UNIVERSITY EU contribution € 621 144,00 Address COLLEGE ROAD LL57 2DG Bangor United Kingdom See on map Region Wales West Wales and The Valleys Gwynedd Activity type Higher or Secondary Education Establishments Administrative Contact Dyfan Griffith (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data Participants (10) Sort alphabetically Sort by EU Contribution Expand all Collapse all CONSIGLIO NAZIONALE DELLE RICERCHE Italy EU contribution € 357 549,00 Address PIAZZALE ALDO MORO 7 00185 Roma See on map Region Centro (IT) Lazio Roma Activity type Research Organisations Administrative Contact Gaetana Irrera (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data AGENCIA ESTATAL CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS Spain EU contribution € 366 858,00 Address CALLE SERRANO 117 28006 Madrid See on map Region Comunidad de Madrid Comunidad de Madrid Madrid Activity type Research Organisations Administrative Contact Carlos Manuel Abad Ruiz (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data HEINRICH-HEINE-UNIVERSITAET DUESSELDORF Germany EU contribution € 369 750,00 Address UNIVERSITAETSSTRASSE 1 40225 Dusseldorf See on map Region Nordrhein-Westfalen Düsseldorf Düsseldorf, Kreisfreie Stadt Activity type Higher or Secondary Education Establishments Administrative Contact Uwe Droste (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS France EU contribution € 363 089,00 Address RUE MICHEL ANGE 3 75794 Paris See on map Region Ile-de-France Ile-de-France Paris Activity type Research Organisations Administrative Contact Jean-Michel Portefaix (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data UNIVERSITE DE BRETAGNE OCCIDENTALE France EU contribution € 369 828,00 Address RUE MATTHIEU GALLOU 3 29238 BREST See on map Region Bretagne Bretagne Finistère Activity type Higher or Secondary Education Establishments Administrative Contact Joel Querellou (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO Canada EU contribution No data Address KINGS COLLEGE CIRCLE 27 M5S 1A1 Toronto See on map Activity type Higher or Secondary Education Establishments Administrative Contact Jennifer Macinnis (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV Germany EU contribution € 277 027,00 Address HOFGARTENSTRASSE 8 80539 Munchen See on map Region Bayern Oberbayern München, Kreisfreie Stadt Activity type Research Organisations Administrative Contact Heike Wojack (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data PHARMA MAR SA Spain EU contribution € 50 000,00 Address AVDA DE LOS REYES 1 POLIGONO INDUSTRIAL LA MINA COLMENAR VIEJO 28770 Madrid See on map Region Comunidad de Madrid Comunidad de Madrid Madrid Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Guillermo Jimenez Díaz (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data EVOXX TECHNOLOGIES GMBH Germany EU contribution € 50 000,00 Address ALFRED NOBEL STRASSE 10 40789 Monheim See on map Region Nordrhein-Westfalen Düsseldorf Mettmann Administrative Contact Thorsten Eggert (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data INSTITUT DE RECHERCHE PIERRE FABRE France EU contribution € 50 000,00 Address PLACE ABEL GANCE 45 92100 Boulogne Billancourt See on map Region Ile-de-France Ile-de-France Hauts-de-Seine Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Vincent Denoel (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data