Objetivo In the present proposal I will describe a novel research agenda for understanding the neural basis of mammalian behavior. Three central problems prevent current research from explaining mammalian behavior in terms of neural mechanisms. First, there is a preponderance of correlative evidence in systems neuroscience. Second there is generally insufficient information about the individual neuron(s) under study. Third, there is a lack of integration of information. Current neuroscience is characterized by strongly diverging research interests and this highly divergent and specialized research program cannot lead to systemic understanding of brain function. We will confront these problems by three novel research approaches: (1) We will establish a causal link between cellular activity and behavior by a single-cell-stimulation / reverse physiology approach. (2) We will obtain rich information about single neurons by whole-cell recordings in awake behaving animals. (3) We will perform a whole-brain-analysis of a novel model organism, the Etruscan shrew, in which we will record the activity of all neurons in the shrew s brain. The research proposed here is unique, because as no other research group investigates brain function by a single-cell-stimulation, by intracellular recordings in freely moving animals, or by whole-brain analysis. The research outlined here will probe the relationship of neural activity and behavior in an entirely unprecedented fashion. Ámbito científico natural sciencesbiological sciencesneurobiologymedical and health sciencesbasic medicinephysiology Palabras clave Reverse Physiology whole-brain-analysis Programa(s) FP7-IDEAS-ERC - Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Tema(s) ERC-AG-LS5 - ERC Advanced Grant - Neurosciences and neural disorders Convocatoria de propuestas ERC-2008-AdG Consulte otros proyectos de esta convocatoria Régimen de financiación ERC-AG - ERC Advanced Grant Institución de acogida HUMBOLDT-UNIVERSITAET ZU BERLIN Aportación de la UE € 2 499 600,00 Dirección UNTER DEN LINDEN 6 10117 Berlin Alemania Ver en el mapa Región Berlin Berlin Berlin Tipo de actividad Higher or Secondary Education Establishments Investigador principal Michael Brecht (Prof.) Contacto administrativo Ulrich Winderl Enlaces Contactar con la organización Opens in new window Sitio web Opens in new window Coste total Sin datos Beneficiarios (1) Ordenar alfabéticamente Ordenar por aportación de la UE Ampliar todo Contraer todo HUMBOLDT-UNIVERSITAET ZU BERLIN Alemania Aportación de la UE € 2 499 600,00 Dirección UNTER DEN LINDEN 6 10117 Berlin Ver en el mapa Región Berlin Berlin Berlin Tipo de actividad Higher or Secondary Education Establishments Investigador principal Michael Brecht (Prof.) Contacto administrativo Ulrich Winderl Enlaces Contactar con la organización Opens in new window Sitio web Opens in new window Coste total Sin datos
