Cel The knowledge about pancreas development and the establishment of pancreatic cell lineages has exploded in recent years. These studies are important in developing strategies for regenerative medicine. On the other hand, pancreatic ductal adenocarcinoma (PDAC) is the tumor with the worst prognosis in humans: its incidence rate is equivalent to its mortality rate, with a median survival of less than 6 months. In this project, we will use retrospective clonal analysis to analyze the clonal structure of the mouse pancreas. Unlike other lineage tracing studies, the technique proposed allows the analysis of individual, low-frequency, clones. By doing this we pretend to dealwith questions such as clonality, clonal size and clonal variation in the embryonic pancreas. Moreover, we aim at developing strategies to analyze quantitatively the adult pancreas, not only in normal conditions but also in situations where the pancreas structure is disrupted by disease. We will thus use models of experimental pancreatitis. In the final step of this project, we pretend to set up the basis to use our clonal approach with murine PDAC murine models, using both genetic mouse models and carcinogen treatment. The work will impy two host groups with distinct and complementary expertise: developmentl biology and pancreas cancer biology. This kind of approach will become important in cancer research in the future in order to understand clonal evolution. The proposed project builds on the experience of the candidate and will allow him to acquire new expertise in cancer biology in order to establish his scientific career in the future. Dziedzina nauki medical and health sciencesclinical medicineoncologyprostate cancersocial sciencessociologydemographymortalitymedical and health sciencesclinical medicineoncologypancreatic cancer Program(-y) FP7-PEOPLE - Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Temat(-y) FP7-PEOPLE-2010-IEF - Marie-Curie Action: "Intra-European fellowships for career development" Zaproszenie do składania wniosków FP7-PEOPLE-2010-IEF Zobacz inne projekty w ramach tego zaproszenia System finansowania MC-IEF - Intra-European Fellowships (IEF) Koordynator FUNDACION SECTOR PUBLICO ESTATAL CENTRO NACIONAL INVESTIGACIONES ONCOLOGICAS CARLOS III Wkład UE € 230 980,00 Adres C MELCHOR FERNANDEZ ALMAGRO 3 28029 Madrid Hiszpania Zobacz na mapie Region Comunidad de Madrid Comunidad de Madrid Madrid Rodzaj działalności Research Organisations Kontakt administracyjny Dolores Liebanes (Ms.) Linki Kontakt z organizacją Opens in new window Strona internetowa Opens in new window Koszt całkowity Brak danych
