Objetivo The knowledge about pancreas development and the establishment of pancreatic cell lineages has exploded in recent years. These studies are important in developing strategies for regenerative medicine. On the other hand, pancreatic ductal adenocarcinoma (PDAC) is the tumor with the worst prognosis in humans: its incidence rate is equivalent to its mortality rate, with a median survival of less than 6 months. In this project, we will use retrospective clonal analysis to analyze the clonal structure of the mouse pancreas. Unlike other lineage tracing studies, the technique proposed allows the analysis of individual, low-frequency, clones. By doing this we pretend to dealwith questions such as clonality, clonal size and clonal variation in the embryonic pancreas. Moreover, we aim at developing strategies to analyze quantitatively the adult pancreas, not only in normal conditions but also in situations where the pancreas structure is disrupted by disease. We will thus use models of experimental pancreatitis. In the final step of this project, we pretend to set up the basis to use our clonal approach with murine PDAC murine models, using both genetic mouse models and carcinogen treatment. The work will impy two host groups with distinct and complementary expertise: developmentl biology and pancreas cancer biology. This kind of approach will become important in cancer research in the future in order to understand clonal evolution. The proposed project builds on the experience of the candidate and will allow him to acquire new expertise in cancer biology in order to establish his scientific career in the future. Ámbito científico medical and health sciencesclinical medicineoncologyprostate cancersocial sciencessociologydemographymortalitymedical and health sciencesclinical medicineoncologypancreatic cancer Programa(s) FP7-PEOPLE - Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Tema(s) FP7-PEOPLE-2010-IEF - Marie-Curie Action: "Intra-European fellowships for career development" Convocatoria de propuestas FP7-PEOPLE-2010-IEF Consulte otros proyectos de esta convocatoria Régimen de financiación MC-IEF - Intra-European Fellowships (IEF) Coordinador FUNDACION SECTOR PUBLICO ESTATAL CENTRO NACIONAL INVESTIGACIONES ONCOLOGICAS CARLOS III Aportación de la UE € 230 980,00 Dirección C MELCHOR FERNANDEZ ALMAGRO 3 28029 Madrid España Ver en el mapa Región Comunidad de Madrid Comunidad de Madrid Madrid Tipo de actividad Research Organisations Contacto administrativo Dolores Liebanes (Ms.) Enlaces Contactar con la organización Opens in new window Sitio web Opens in new window Coste total Sin datos