Cel Interactions between neurons and glial cells underlie the normal development, structure and function of the nervous system. Perturbation of this communication occurs during injury, in acquired or hereditary neuropathic diseases of the central and peripheral nervous systems, and with ageing. However, the specific nature and the physiological significance of neuron-glia interactions remain largely unknown. We propose here the use of a microfluidic co-culture platform to characterize and investigate the role of non-synaptic responses of glial cells following stimulation of neuronal activity. In particular, we will co-culture neurons and glial cells of the peripheral nervous system, and monitor glia-specific changes at the transcriptome- and the secretome-levels, after manipulation of the electrical activity of neurons. We will subsequently interfere with the identified signaling pathways, and study effects on neuronal structure and function. Following this in vitro approach, we expect to identify potential mediators of the axon-glia communication and decipher their role in maintaining the nervous system integrity and function. Dziedzina nauki natural sciencesbiological sciencesneurobiologynatural sciencesphysical sciencesclassical mechanicsfluid mechanicsmicrofluidics Program(-y) FP7-PEOPLE - Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Temat(-y) FP7-PEOPLE-2011-IIF - Marie Curie Action: "International Incoming Fellowships" Zaproszenie do składania wniosków FP7-PEOPLE-2011-IIF Zobacz inne projekty w ramach tego zaproszenia System finansowania MC-IIF - International Incoming Fellowships (IIF) Koordynator UNIVERSITE DE LAUSANNE Wkład UE € 184 709,40 Adres QUARTIER UNIL CENTRE - BATIMENT UNICENTRE 1015 LAUSANNE Szwajcaria Zobacz na mapie Region Schweiz/Suisse/Svizzera Région lémanique Vaud Rodzaj działalności Higher or Secondary Education Establishments Kontakt administracyjny Roman Chrast (Prof.) Linki Kontakt z organizacją Opens in new window Strona internetowa Opens in new window Koszt całkowity Brak danych
