Objetivo The overall objective of this proposal is to develop a fast and cost-effective diagnostic tool for bacterial meningitis, i.e. the detection of Streptococcus pneumoniae and Neisseria meningitidis in cerebrospinal fluid.Kits, consisting of disposable sensing chips and separate detector units, will be developed. The tool shall be low priced and easy to use so that health workers with limited analytical training can employ the kits in the fieldThe tool shall lead to a faster diagnosis, speeding up a targeted antibiotics treatment, thus improving the survival chances of the patient, while facilitating the identification of the infection source and the isolation of individuals, in order to halt the epidemicsThe main project novelty is the use of aptamer receptors. Aptamers have several advantages over conventional antibodies e.g. significantly lower price, fast development and increased stability.Three sensor technologies will be developed aiming to obtain at least one commercial product by the end of the project. All technologies share the same aptamers and surface activation of the active area.The project success depends on a tight and well-planned collaboration between partners. Partner 1 will develop the S. pneumoniae and N. meningitidis aptamers, and will provide already available micro-organism specific aptamers for parallel sensor development.The near-market technology is evanescent fluorescence, already commercialised by Partner 2. Adaptation of the aptamers and of the Eva-Sensor Chip, will be done and validated in collaboration with Partners 1 & 3.Partner 1 will develop sensors based on microelectromechanical systems and liquid crystals. Either of these–acoustic and volumetric– technologies have, with limited commercial success, been used with molecular targets. Compared hereto targeting micro-organisms generate amplified signals. Partner 3 will design the fluidic chip incorporating the sensor. The resulting system will be commercialised by Partners 2 & 3 Ámbito científico natural sciencesbiological sciencesmicrobiologybacteriologymedical and health sciencesbasic medicinepharmacology and pharmacypharmaceutical drugsantibioticsengineering and technologyelectrical engineering, electronic engineering, information engineeringelectronic engineeringsensorsengineering and technologymaterials engineeringliquid crystals Programa(s) FP7-HEALTH - Specific Programme "Cooperation": Health Tema(s) HEALTH.2012.2.3.0-1 - Diagnostics for infectious diseases in humans Convocatoria de propuestas FP7-HEALTH-2012-INNOVATION-2 Consulte otros proyectos de esta convocatoria Régimen de financiación CP-FP - Small or medium-scale focused research project Coordinador UNIVERSIDAD POLITECNICA DE MADRID Aportación de la UE € 1 062 578,28 Dirección CALLE RAMIRO DE MAEZTU 7 EDIFICIO RECTORADO 28040 Madrid España Ver en el mapa Región Comunidad de Madrid Comunidad de Madrid Madrid Tipo de actividad Higher or Secondary Education Establishments Contacto administrativo Gonzalo León (Prof.) Enlaces Contactar con la organización Opens in new window Sitio web Opens in new window Coste total Sin datos Participantes (3) Ordenar alfabéticamente Ordenar por aportación de la UE Ampliar todo Contraer todo DAVOS DIAGNOSTICS AG Suiza Aportación de la UE € 890 631,40 Dirección OBERE STRASSE 22 7270 DAVOS PLATZ Ver en el mapa Tipo de actividad Private for-profit entities (excluding Higher or Secondary Education Establishments) Contacto administrativo Max Wiki (Dr.) Enlaces Contactar con la organización Opens in new window Sitio web Opens in new window Coste total Sin datos JONSMAN INNOVATION APS Dinamarca Aportación de la UE € 183 208,40 Dirección HOVEDVEJEN 1d 3330 GORLOSE Ver en el mapa Región Danmark Hovedstaden Nordsjælland Tipo de actividad Private for-profit entities (excluding Higher or Secondary Education Establishments) Contacto administrativo Jacques Jonsman (Dr.) Enlaces Contactar con la organización Opens in new window Sitio web Opens in new window Coste total Sin datos BIOAPTER SOCIEDAD LIMITADA La participación finalizó España Aportación de la UE € 38 085,17 Dirección CALLE FORMENTERA EDIFICIO LAS ROZAS LOCAL 5 3 28230 LAS ROZAS MADRID Ver en el mapa Tipo de actividad Private for-profit entities (excluding Higher or Secondary Education Establishments) Contacto administrativo Javier Vinós (Dr.) Enlaces Contactar con la organización Opens in new window Coste total Sin datos