Objetivo "During minimally invasive procedures, accurate identification of tissue targets is of critical importance to maximise clinical outcomes. Ultrasound imaging is widely used for real-time guidance, but in many clinical contexts it provides inadequate contrast for tissue targets. The overall objective of this translational research proposal is to develop and test a novel framework for guiding minimally invasive procedures that will dramatically enhance image contrast for a wide range of tissue structures. One of the central components of this framework will be a new modality called photoacoustics, which involves acoustic imaging of specific molecular tissue constituents that absorb pulsed excitation light. With Objective 1, we will combine ultrasound imaging with photoacoustic imaging into a novel clinical system that will be optimised for guiding minimally invasive procedures in human patients. With Objective 2, we will obtain multi-spectral photoacoustic images that provide contrast for molecules such as haemoglobins, water, and lipids, and we will co-register them with ultrasound images. With Objective 3, we will perform pre-clinical and clinical pilot studies to assess the potential of the new image guidance framework for improving the accuracy of particular minimally invasive procedures in the field of interventional pain management. This proposal is timely because there is intense scientific and clinical interest in photoacoustic imaging, but this modality has not yet been extended to the guidance of minimally invasive procedures. With a Starting Grant from the ERC, I will initiate a multi-disciplinary translational research group that is focused on developing new imaging technologies for improving the clinical outcomes of minimally invasive procedures." Ámbito científico natural sciencesbiological sciencesbiochemistrybiomoleculeslipidsnatural sciencesphysical sciencesacousticsultrasound Programa(s) FP7-IDEAS-ERC - Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Tema(s) ERC-SG-LS7 - Applied life sciences, biotechnology and bioengineering: agricultural, animal, fishery, forestry/food sciences; biotechnology, chemical biology, genetic engineering, synthetic biology, industrial biosciences; environmental biotechnology. Convocatoria de propuestas ERC-2012-StG_20111109 Consulte otros proyectos de esta convocatoria Régimen de financiación ERC-SG - ERC Starting Grant Institución de acogida UNIVERSITY COLLEGE LONDON Aportación de la UE € 1 499 231,00 Dirección GOWER STREET WC1E 6BT LONDON Ver en el mapa Tipo de actividad Higher or Secondary Education Establishments Investigador principal Adrien Desjardins (Dr.) Contacto administrativo Giles Machell (Mr.) Enlaces Contactar con la organización Opens in new window Sitio web Opens in new window Coste total Sin datos Beneficiarios (1) Ordenar alfabéticamente Ordenar por aportación de la UE Ampliar todo Contraer todo UNIVERSITY COLLEGE LONDON Aportación de la UE € 1 499 231,00 Dirección GOWER STREET WC1E 6BT LONDON Ver en el mapa Tipo de actividad Higher or Secondary Education Establishments Investigador principal Adrien Desjardins (Dr.) Contacto administrativo Giles Machell (Mr.) Enlaces Contactar con la organización Opens in new window Sitio web Opens in new window Coste total Sin datos
