Protein dynamics and misfolding: the case study of a multidomain protein related to an amyloid disease

Projektinformationen

AggregAT3

ID Finanzhilfevereinbarung: 331130

Projekt abgeschlossen

Startdatum 1 März 2013

Enddatum 28 Februar 2015

Finanziert unter

• Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)

Gesamtkosten € 230 809,80

EU-Beitrag € 230 809,80

Koordiniert durch

KOBENHAVNS UNIVERSITET
Denmark

Ziel

The present proposal aims to study the relationships existing between protein structural dynamics and pathological aggregation of the multidomain N-terminal part of the polyglutamine (polyQ) protein ataxin-3. By means of an integrated approach combining advanced NMR and computational techniques, the applicant plans to investigate low frequencies native-like states responsible of aberrant protein-protein interactions leading to first amyloid aggregates. These species in AT3 predominantly involve the globular structured N-terminal domain and are polyQ independent. Results of this project will boost the knowledge related to the first misfolding events leading to AT3 pathological aggregation as well as our understanding on subtle misfolding events triggering protein aggregation of folded globular proteins.

Wissenschaftliches Gebiet

• natural sciences › biological sciences › biochemistry › biomolecules › proteins › proteomics

Programm/Programme

• FP7-PEOPLE - Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)

Thema/Themen

• FP7-PEOPLE-2012-IEF - Marie-Curie Action: "Intra-European fellowships for career development"

Aufforderung zur Vorschlagseinreichung

FP7-PEOPLE-2012-IEF
Andere Projekte für diesen Aufruf anzeigen

Finanzierungsplan

MC-IEF - Intra-European Fellowships (IEF)

Koordinator

KOBENHAVNS UNIVERSITET

Kontakt Verwaltung

Ivan Kristoffersen (Mr.)

• EU-Beitrag: € 230 809,80
• Adresse: NORREGADE 10 ; 1165 Kobenhavn ; Dänemark
• Region: Danmark › Hovedstaden › Byen København
• Aktivitätstyp: Higher or Secondary Education Establishments
• Gesamtkosten: Keine Daten