Objective The retina is a highly complex biological system that accommodates both numerous tissue-specific and ubiquitously expressed developmental and pathologic pathways. The number of genes identified in Inherited Retinal Degenerations (IRD) has steadily increased. The commonest cause of blindness, (12.5 Million affected in Europe) Age-Related-Macular-Degeneration (ARMD), is likely to depend on both mostly unknown genetic and modifying factors. Preventing blindness from IRD and ARMD requires the understanding of the genetic and cellular interactions controlling retinal development, maintenance and function.In EVI-GENORET 24 academic and industrial partners form five interacting components (phenotyping, gcnotyping, development, therapy and functional gene analysis) to establish working platforms, share tools and knowledge within and outside the academic community (dissemination through patient organisations and transfer to industrial partners).This IP, spanning from the biology of seeing to the fight against retinal blindness, will implement an accurate clinical and molecular classification of disease, identify novel retinal genes and pathways and define the context dependent functions of these genes in normal and degenerating tissue. We will employ transcriptome, proteomics, protcin-interactome analyses, functional cellular and biochemical assays, biomformatics and model organisms to analyse patterns of gene expression and gene function in retinal development, normal function and degeneration. The unique knowledge base on molecular networks thus generated will facilitate identification and validation of novel therapeutic targets, of broad interest. Developing stem cell culture methods and new approaches to gene and drug delivery mechanisms should provide novel tools for therapy after testing in this privileged organ... Fields of science medical and health sciencesclinical medicineophthalmologymedical and health sciencesmedical biotechnologycells technologiesstem cellsengineering and technologyelectrical engineering, electronic engineering, information engineeringinformation engineeringtelecommunicationstelecommunications networksdata networksmedical and health sciencesclinical medicineembryologynatural sciencescomputer and information sciencesdatabasesrelational databases Keywords Age-related macular degeneration (AMD) Animal Dystrophies Animal mutants Correlation Gene expression Genotype Genotype-Phenotype-Correlation Genotype-Phenotype-Correlation # Phenotype Photoreceptors Retinal Developement Retinal Dystrophies Vision Programme(s) FP6-LIFESCIHEALTH - Life sciences, genomics and biotechnology for health: Thematic Priority 1 under the Focusing and Integrating Community Research programme 2002-2006. Topic(s) LSH-2003-1.1.5-4 - Functional genomics of the retina in health and disease Call for proposal FP6-2003-LIFESCIHEALTH-I See other projects for this call Funding Scheme IP - Integrated Project Coordinator EUROPEAN VISION INSTITUTE EEIG EU contribution No data Address Rue du Trône, 98 BRUSSELS Belgium See on map Links Website Opens in new window Total cost No data Participants (24) Sort alphabetically Sort by EU Contribution Expand all Collapse all INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE France EU contribution No data Address 101, Rue de Tolbiac PARIS See on map Links Website Opens in new window Total cost No data UNIVERSITY COLLEGE LONDON, INSTITUTE OF OPHTHALMOLOGY United Kingdom EU contribution No data Address 11-43 Bath Street LONDON See on map Links Website Opens in new window Total cost No data EBERHARD-KARLS-UNIVERSITAET TUEBINGEN Germany EU contribution No data Address Wilhelmstr. 5 N/A TUEBINGEN See on map Links Website Opens in new window Total cost No data AIBILI - ASSOCIAÇÃO PARA INVESTIGAÇÃO BIOMÉDICA E INOVAÇÃO EM LUZ E IMAGEM Portugal EU contribution No data Address Azinhaga de Santa Comba - Celas N/A COIMBRA See on map Links Website Opens in new window Total cost No data FONDAZIONE TELETHON Italy EU contribution No data Address VIA GUGLIELMO SALICETO, 5 ROMA See on map Links Website Opens in new window Total cost No data STICHTING KATHOLIEKE UNIVERSITEIT, MORE PARTICULARLY THE UNIVERSITY MEDICAL CENTRE NIJMEGEN Netherlands EU contribution No data Address Geert Grooteplein 10 9101 NIJMEGEN See on map Links Website Opens in new window Total cost No data LUND UNIVERSITY Sweden EU contribution No data Address Paradisgatan 5C 117 LUND See on map Links Website Opens in new window Total cost No data UNIVERSITY OF MILANO BICOCCA Italy EU contribution No data Address Piazza dell'Ateneo Nuovo, 1' MILAN See on map Links Website Opens in new window Total cost No data MEDICAL RESEARCH COUNCIL United Kingdom EU contribution No data Address 20 Park Crescent LONDON See on map Links Website Opens in new window Total cost No data GSF-FORSCHUNGSZENTRUM FÜR UMWELT UND GESUNDHEIT GMBH Germany EU contribution No data Address Ingolstaedter Landstrasse 1 NEUHERBERG See on map Links Website Opens in new window Total cost No data UNIVERSITY HOSPITAL HAMBURG-EPPENDORF - UNIVERSITÄTSKLINIKUM HAMBURG EPPENDORF Germany EU contribution No data Address Martinistr. 52 HAMBURG See on map Links Website Opens in new window Total cost No data UNIVERSITY OF ZUERICH Switzerland EU contribution No data Address Raemistrasse 71 N/A ZUERICH See on map Links Website Opens in new window Total cost No data UNIVERSITÄTSKLINIKUM BONN Germany EU contribution No data Address Sigmund-Freud-Strasse 25 BONN See on map Links Website Opens in new window Total cost No data THE PROVOST, FELLOWS AND SCHOLARS OF THE COLLEGE OF THE HOLY AND UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN (HEREINAFTER TCD) Ireland EU contribution No data Address College Green DUBLIN See on map Links Website Opens in new window Total cost No data RETINA INTERNATIONAL Switzerland EU contribution No data Address Ausstellungsstr. 36 N/A ZUERICH See on map Links Website Opens in new window Total cost No data RESEARCH CENTRE JUELICH GMBH Germany EU contribution No data Address Leo-Brandt-Strasse JUELICH See on map Links Website Opens in new window Total cost No data GENABLE TEHNOLOGIES LIMITED Ireland EU contribution No data Address SMURFIT Institute of Genetics, Trinity College Dublin DUBLIN See on map Links Website Opens in new window Total cost No data QUEEN'S UNIVERSITY BELFAST United Kingdom EU contribution No data Address University Road BELFAST, NORTHERN IRELAND See on map Links Website Opens in new window Total cost No data CENTRE EUROPÉEN POUR LA RECHERCHE EN BIOLOGIE ET MÉDECINE- GROUPEMENT D'INTERET ECONOMIQUE France EU contribution No data Address 1 rue Laurent Fries 10142 ILLKIRCH See on map Links Website Opens in new window Total cost No data GENOWAY France EU contribution No data Address 181 Avenue Jean Jaures LYON See on map Links Website Opens in new window Total cost No data FUNDACION JIMENEZ DIAZ UTE Spain EU contribution No data Address Av Reyes Catolicos 2 MADRID See on map Links Website Opens in new window Total cost No data NATIONAL AND KAPODISTRIAN UNIVERSITY OF ATHENS Greece EU contribution No data Address Chr. Lada 6 ATHENS See on map Links Website Opens in new window Total cost No data INSERM TRANSFERT SA France EU contribution No data Address 101 Rue de Tolbiac PARIS See on map Links Website Opens in new window Total cost No data UNIVERSITÀ DI MODENA E REGGIO EMILIA Italy EU contribution No data Address via dell'Università, 4 MODENA See on map Links Website Opens in new window Total cost No data
