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Functional genomics of the retina in health and disease

Objective

The retina is a highly complex biological system that accommodates both numerous tissue-specific and ubiquitously expressed developmental and pathologic pathways. The number of genes identified in Inherited Retinal Degenerations (IRD) has steadily increased. The commonest cause of blindness, (12.5 Million affected in Europe) Age-Related-Macular-Degeneration (ARMD), is likely to depend on both mostly unknown genetic and modifying factors. Preventing blindness from IRD and ARMD requires the understanding of the genetic and cellular interactions controlling retinal development, maintenance and function.
In EVI-GENORET 24 academic and industrial partners form five interacting components (phenotyping, gcnotyping, development, therapy and functional gene analysis) to establish working platforms, share tools and knowledge within and outside the academic community (dissemination through patient organisations and transfer to industrial partners).
This IP, spanning from the biology of seeing to the fight against retinal blindness, will implement an accurate clinical and molecular classification of disease, identify novel retinal genes and pathways and define the context dependent functions of these genes in normal and degenerating tissue. We will employ transcriptome, proteomics, protcin-interactome analyses, functional cellular and biochemical assays, biomformatics and model organisms to analyse patterns of gene expression and gene function in retinal development, normal function and degeneration. The unique knowledge base on molecular networks thus generated will facilitate identification and validation of novel therapeutic targets, of broad interest. Developing stem cell culture methods and new approaches to gene and drug delivery mechanisms should provide novel tools for therapy after testing in this privileged organ...

Field of science

  • /natural sciences/biological sciences/biochemistry/biomolecules/proteins/proteomics
  • /natural sciences/computer and information sciences/databases
  • /medical and health sciences/medical biotechnology/cells technologies/stem cells
  • /medical and health sciences/clinical medicine/ophthalmology
  • /engineering and technology/electrical engineering, electronic engineering, information engineering/information engineering/telecommunications/telecommunications network/data network

Call for proposal

FP6-2003-LIFESCIHEALTH-I
See other projects for this call

Funding Scheme

IP - Integrated Project

Coordinator

EUROPEAN VISION INSTITUTE EEIG
Address
Rue Du Trône, 98
Brussels
Belgium

Participants (24)

INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE
France
Address
101, Rue De Tolbiac
Paris
UNIVERSITY COLLEGE LONDON, INSTITUTE OF OPHTHALMOLOGY
United Kingdom
Address
11-43 Bath Street
London
EBERHARD-KARLS-UNIVERSITAET TUEBINGEN
Germany
Address
Wilhelmstr. 5
N/A Tuebingen
AIBILI - ASSOCIAÇÃO PARA INVESTIGAÇÃO BIOMÉDICA E INOVAÇÃO EM LUZ E IMAGEM
Portugal
Address
Azinhaga De Santa Comba - Celas
N/A Coimbra
FONDAZIONE TELETHON
Italy
Address
Via Guglielmo Saliceto, 5
Roma
STICHTING KATHOLIEKE UNIVERSITEIT, MORE PARTICULARLY THE UNIVERSITY MEDICAL CENTRE NIJMEGEN
Netherlands
Address
Geert Grooteplein 10
9101 Nijmegen
LUND UNIVERSITY
Sweden
Address
Paradisgatan 5C
117 Lund
UNIVERSITY OF MILANO BICOCCA
Italy
Address
Piazza Dell'ateneo Nuovo, 1'
Milan
MEDICAL RESEARCH COUNCIL
United Kingdom
Address
20 Park Crescent
London
GSF-FORSCHUNGSZENTRUM FÜR UMWELT UND GESUNDHEIT GMBH
Germany
Address
Ingolstaedter Landstrasse 1
Neuherberg
UNIVERSITY HOSPITAL HAMBURG-EPPENDORF - UNIVERSITÄTSKLINIKUM HAMBURG EPPENDORF
Germany
Address
Martinistr. 52
Hamburg
UNIVERSITY OF ZUERICH
Switzerland
Address
Raemistrasse 71
N/A Zuerich
UNIVERSITÄTSKLINIKUM BONN
Germany
Address
Sigmund-freud-strasse 25
Bonn
THE PROVOST, FELLOWS AND SCHOLARS OF THE COLLEGE OF THE HOLY AND UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN (HEREINAFTER TCD)
Ireland
Address
College Green
Dublin
RETINA INTERNATIONAL
Switzerland
Address
Ausstellungsstr. 36
N/A Zuerich
RESEARCH CENTRE JUELICH GMBH
Germany
Address
Leo-brandt-strasse
Juelich
GENABLE TEHNOLOGIES LIMITED
Ireland
Address
Smurfit Institute Of Genetics, Trinity College Dublin
Dublin
QUEEN'S UNIVERSITY BELFAST
United Kingdom
Address
University Road
Belfast, Northern Ireland
CENTRE EUROPÉEN POUR LA RECHERCHE EN BIOLOGIE ET MÉDECINE- GROUPEMENT D'INTERET ECONOMIQUE
France
Address
1 Rue Laurent Fries
10142 Illkirch
GENOWAY
France
Address
181 Avenue Jean Jaures
Lyon
FUNDACION JIMENEZ DIAZ UTE
Spain
Address
Av Reyes Catolicos 2
Madrid
NATIONAL AND KAPODISTRIAN UNIVERSITY OF ATHENS
Greece
Address
Chr. Lada 6
Athens
INSERM TRANSFERT SA
France
Address
101 Rue De Tolbiac
Paris
UNIVERSITÀ DI MODENA E REGGIO EMILIA
Italy
Address
Via Dell'università, 4
Modena