Objetivo The neural assembly underlying the formation of functional networks in the cerebral cortex constitutes one of the most complex neuronal systems in the brain. Much of this complexity arises during development through the interaction of two distinct neuronal types, the glutamatergic projection neurons and g-aminobutyric containing (GABAergic) interneurons. Recently, interneuron dysfunction has been associated with severe neurological and psychiatric disorders (e.g. epilepsy, schizophrenia and bipolar disorder). In order to achieve true progress in the understanding of cortical development and of neurological diseases associated with cortical interneuron dysfunction, a complete account of the development of its neuronal constituents is essential. In that sense, despite the detailed picture that is emerging about the development of cortical projection neurons, the mechanisms underlying the development of interneurons in the cerebral cortex have remained poorly defined. The general goal of the network is to obtain a comprehensive definition of the cellular and molecular mechanisms controlling the development of cortical interneurons. To reach this aim, we will take a multidisciplinary approach by combining novel bioinformatic and genomics applications, cutting-edge imaging techniques, and conventional cellular, molecular and electrophysiological methodologies. In addition, we will develop new genetic tools to engineer developmental models of cortical disorders involving interneuron deficiency. Thus, successful execution of the project will result in: i) New knowledge of the mechanisms underlying the specification, migration and terminal differentiation of cortical interneurons, and ii) Generation of new developmental models of cortical disorders resulting from interneuron deficiency. Ámbito científico medical and health sciencesbasic medicineneurologyepilepsymedical and health sciencesclinical medicinepsychiatryschizophrenianatural sciencesbiological sciencesgeneticsgenomes Palabras clave Cerebral cortex GABA cell-therapy cortical disorders development epilepsy genomics microarrays migration mouse genetics mouse models neuron patterning schizophrenia synaptogenesis therapy Programa(s) FP6-LIFESCIHEALTH - Life sciences, genomics and biotechnology for health: Thematic Priority 1 under the Focusing and Integrating Community Research programme 2002-2006. Tema(s) LSH-2003-2.1.3-5 - Cortical development Convocatoria de propuestas FP6-2003-LIFESCIHEALTH-I Consulte otros proyectos de esta convocatoria Régimen de financiación STREP - Specific Targeted Research Project Coordinador CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS Aportación de la UE Sin datos Dirección Serrano 117 MADRID España Ver en el mapa Coste total Sin datos Participantes (7) Ordenar alfabéticamente Ordenar por aportación de la UE Ampliar todo Contraer todo FOUNDATION FOR RESEARCH AND TECHNOLOGY - HELLAS Grecia Aportación de la UE Sin datos Dirección Vassilika Vouton 1527 HERAKLION Ver en el mapa Enlaces Sitio web Opens in new window Coste total Sin datos MEDICAL RESEARCH COUNCIL Reino Unido Aportación de la UE Sin datos Dirección 20 Park Crescent LONDON Ver en el mapa Coste total Sin datos CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE Francia Aportación de la UE Sin datos Dirección 3 Rue Michel-Ange PARIS Ver en el mapa Coste total Sin datos ORYZON GENOMICS SA España Aportación de la UE Sin datos Dirección PARC CIENTIFIC DE BARCELONA - C/ JOSEP SAMITIER 1 BARCELONA Ver en el mapa Coste total Sin datos UNIVERSIDAD MIGUEL HERNANDEZ España Aportación de la UE Sin datos Dirección Avda. de la Universidad s/n ELCHE, ALICANTE Ver en el mapa Coste total Sin datos FUNDACIÓN PARA LA INVESTIGACIÓN BIOMÉDICA DEL HOSPITAL UNIVERSITARIO RAMÓN Y CAJAL España Aportación de la UE Sin datos Dirección Ctra Colmenar Km 9 Planta -2D MADRID Ver en el mapa Coste total Sin datos FONDAZIONE TELETHON Italia Aportación de la UE Sin datos Dirección VIA SALICETO, 5 ROME Ver en el mapa Coste total Sin datos