Objective Surfaces of medical materials and devices that come into direct contact with human tissues need to be fine-tuned with regard to both physical and biological properties. A cross-disciplinary nanotechnology approach is proposed that aims to impart material surfaces with appropriate biological properties. This approach gathers competences from across Europe and includes a critical mass of resources necessary to accelerate the R&D process. The biomolecules that are to be grafted onto surfaces to functio n as nanocoatings have been selected from a class of complex polysaccharides, the pectic rhamnogalacturonans, that are known to possess anti-inflammatory properties as well as desirable physical properties. Sugar molecular structure will be altered in a controlled manner so as to favourably influence living cell behaviour around the coated materials. Current knowledge and expertise within our project team covers technologies to manufacture a range of tailored polysaccharides, to attach the molecules co valently to relevant biomaterials (e.g. titanium for dental implants) and to characterize the grafted surfaces and to assess their biocompatibility both in vitro and in vivo. We expect to generate evidence demonstrating both the antiinflammatory and mole cular flexibility of the innovative nanocoatings. This will open a platform for the development of a large range of applications that will be defined through industrial guidance and result in solutions for current bioincompatibility problems of various i mplantable devices. Industrial monitoring and engineering will allow the exploration of a wide range of applications (breast implants, meshes etc.). For one of these: the dental application, the involvement of industrial SMEs covers the full production c hain from raw material to prototype design which will lead in to a demonstration phase. Fields of science medical and health sciencesclinical medicineodontologydental implantologyengineering and technologynanotechnologynatural sciencesbiological sciencesbiochemistrybiomoleculescarbohydratesmedical and health sciencesmedical biotechnologyimplantsbreast implantsengineering and technologyindustrial biotechnologybiomaterials Keywords Nanotechnology Programme(s) FP6-NMP - Nanotechnologies and nanosciences, knowledge-based multifunctional materials and new production processes and devices: thematic priority 3 under the 'Focusing and integrating community research' of the 'Integrating and strengthening the European Research Area' specific programme 2002-2006. Topic(s) NMP-2003-3.4.2.2-3 - Intelligent' bio-materials for tissue repair and regeneration NMP-2003-3.4.1.2-1 - New knowledge on interfaces for new applications Call for proposal FP6-2003-NMP-TI-3-MAIN See other projects for this call Funding Scheme STIP - Specific Targeted Innovation Project Coordinator DIVERGENT SA - GROUPE UTC EU contribution No data Address Centre de Transfert - Rond Point Guy Denielou, 66 avenue de Landshut COMPIEGNE France See on map Links Website Opens in new window Total cost No data Participants (11) Sort alphabetically Sort by EU Contribution Expand all Collapse all AGLIATI SRL Italy EU contribution No data Address VIA STATALE BRIANTEA KM. 12,7 PALAZZAGO See on map Links Website Opens in new window Total cost No data DANISH INSTITUTE OF AGRICULTURAL SCIENCES Denmark EU contribution No data Address Blichers Alle 20 TJELE See on map Links Website Opens in new window Total cost No data EUROPEAN COMMISSION, JOINT RESEARCH CENTRE Belgium EU contribution No data Address Rue de la Loi 200 BRUXELLES See on map Links Website Opens in new window Total cost No data NOBIL BIO RICERCHE S.R.L. Italy EU contribution No data Address Strada San Rocco 36 VILLAFRANCA D'ASTI' See on map Links Website Opens in new window Total cost No data POALIS A/S Denmark EU contribution No data Address Bulowsvej 25 FREDERIKSBERG See on map Links Website Opens in new window Total cost No data STATICE SANTE France EU contribution No data Address 9 RUE THOMAS EDISON BESANCON See on map Links Website Opens in new window Total cost No data UNIVERSITA' DEGLI STUDI DI TRENTO Italy EU contribution No data Address See on map Total cost No data UNIVERSITE DE TECHNOLOGIE DE COMPIEGNE France EU contribution No data Address Centre Benjamin Franklin, Rue Roger Couttolenc COMPIEGNE See on map Links Website Opens in new window Total cost No data UNIVERSITY OF LEEDS United Kingdom EU contribution No data Address Woodhouse Lane LEEDS See on map Links Website Opens in new window Total cost No data UNIVERSITY OF OULU Finland EU contribution No data Address Pentti Kaiteran katu 1 OULU See on map Links Website Opens in new window Total cost No data WAGENINGEN UNIVERSITY Netherlands EU contribution No data Address Costerweg 50 WAGENINGEN See on map Links Website Opens in new window Total cost No data