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Nanobiotechnology for the coating of medical devices

Objective

Surfaces of medical materials and devices that come into direct contact with human tissues need to be fine-tuned with regard to both physical and biological properties. A cross-disciplinary nanotechnology approach is proposed that aims to impart material surfaces with appropriate biological properties. This approach gathers competences from across Europe and includes a critical mass of resources necessary to accelerate the R&D process. The biomolecules that are to be grafted onto surfaces to functio n as nanocoatings have been selected from a class of complex polysaccharides, the pectic rhamnogalacturonans, that are known to possess anti-inflammatory properties as well as desirable physical properties. Sugar molecular structure will be altered in a controlled manner so as to favourably influence living cell behaviour around the coated materials. Current knowledge and expertise within our project team covers technologies to manufacture a range of tailored polysaccharides, to attach the molecules co valently to relevant biomaterials (e.g. titanium for dental implants) and to characterize the grafted surfaces and to assess their biocompatibility both in vitro and in vivo. We expect to generate evidence demonstrating both the antiinflammatory and mole cular flexibility of the innovative nanocoatings. This will open a platform for the development of a large range of applications that will be defined through industrial guidance and result in solutions for current bioincompatibility problems of various i mplantable devices. Industrial monitoring and engineering will allow the exploration of a wide range of applications (breast implants, meshes etc.). For one of these: the dental application, the involvement of industrial SMEs covers the full production c hain from raw material to prototype design which will lead in to a demonstration phase.

Call for proposal

FP6-2003-NMP-TI-3-MAIN
See other projects for this call

Funding Scheme

STIP - Specific Targeted Innovation Project

Coordinator

DIVERGENT SA - GROUPE UTC
Address
Centre De Transfert - Rond Point Guy Denielou, 66 Avenue De Landshut
Compiegne
France

Participants (11)

AGLIATI SRL
Italy
Address
Via Statale Briantea Km. 12,7
Palazzago
DANISH INSTITUTE OF AGRICULTURAL SCIENCES
Denmark
Address
Blichers Alle 20
Tjele
EUROPEAN COMMISSION, JOINT RESEARCH CENTRE
Belgium
Address
Rue De La Loi 200
Bruxelles
NOBIL BIO RICERCHE S.R.L.
Italy
Address
Strada San Rocco 36
Villafranca D'asti'
POALIS A/S
Denmark
Address
Bulowsvej 25
Frederiksberg
STATICE SANTE
France
Address
9 Rue Thomas Edison
Besancon
UNIVERSITA' DEGLI STUDI DI TRENTO
Italy
UNIVERSITE DE TECHNOLOGIE DE COMPIEGNE
France
Address
Centre Benjamin Franklin, Rue Roger Couttolenc
Compiegne
UNIVERSITY OF LEEDS
United Kingdom
Address
Woodhouse Lane
Leeds
UNIVERSITY OF OULU
Finland
Address
Pentti Kaiteran Katu 1
Oulu
WAGENINGEN UNIVERSITY
Netherlands
Address
Costerweg 50
Wageningen